血管源性轻度认知障碍合并代谢综合征患者的认知障碍特点和中医证候特征  

Cognitive impairment performance and TCM syndrome in the vascular mild cognitive impairment patients with metabolic syndrome

作　　者：陈宝鑫[1] 金香兰[1] 张允岭[1] 郑硕[1] 张艳霞[1] 南一楠[1] 牛焕敏[1] 何婷婷[1] 白文[2] 戴中[2] 赵建军[3] 曹晓兰[4] 陈志强[5] 张玉莲[6] 田军彪[5] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京大学人民医院,北京100044 [3]长春中医药大学第一附属医院,长春130021 [4]山东中医药大学附属医院,济南250011 [5]河北医科大学中医院,石家庄050011 [6]天津中医药大学第二附属医院,天津300150

出　　处：《中华中医药杂志》2012年第2期374-378,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2008年中医药行业科研专项(No.200807011);2010年中医药行业科研专项(No.201007002);2010年度北京市社区中医药服务科技示范项目;北京市新医药学科群建设项目(No.XK100270569);北京中医药大学创新团队发展计划;北京中医药大学科研基金;211工程重点学科建设项目~~

摘　　要：目的:研究血管源性轻度认知障碍合并代谢综合征患者的认知障碍特点和中医证候特征。方法:将血管源性轻度认知障碍患者分为代谢综合征组(54例)和非代谢综合征组(142例),采用蒙特利尔认知量表(MoCA)进行认知功能测评,制定中医证候观察表采集中医四诊信息。结果:代谢综合征组的MoCA总分、注意力、抽象能力明显低于非代谢综合征组,其余各项无统计学差异。代谢综合征组分数与MoCA的得分有一定的相关性,相关系数r=-0.17,P=0.04。代谢综合征组痰、血瘀最为多见,且明显高于非代谢综合征组(P<0.01),非代谢综合征组以阴虚、血虚最为多见。两组的病位均主要涉及肾、肝,其次为脾、心,两组间无显著性差异。结论:代谢综合征增加轻度认知障碍的患病风险。血管源性轻度认知障碍合并代谢综合征患者,在正气亏虚的基础上,多有痰湿瘀血停滞。Objective： To investigate the cognitive impairment performance and TCM syndrome in the vascular mild cognitive impairment patients with metabolic syndrome.Methods： The vascular mild cognitive impairment patients were divided into group of patients with metabolic syndrome（54 cases） and group of patients without metabolic syndrome（142 cases）.Cognitive function were assessed using MoCA scale.Chinese medical information were collected.Results： Patients with metabolic syndrome had lower MoCA total score,attention and abstraction ability than patients without metabolic syndrome,but no significant difference were shown in the rest of the cognitive function fields.MoCA were correlated with the number of metabolic syndrome components（r=-0.17,P=0.04）.Phlegm,blood stasis were the most common TCM syndrome in the metabolic syndrome group,and significantly higher than the group without metabolic syndrome group（P0.01）.Yin deficiency and blood deficiency were the most common TCM syndrome in the group without metabolic syndrome.The main location of disease were both in kidney,liver,spleen,heart in both group.Conclusion： Metabolic syndrome increased the risk of mild cognitive impairment.Vascular mild cognitive impairment patients with metabolic syndrome usually had phlegm and blood stasis based on deficiency.

关 键 词：血管源性轻度认知障碍 代谢综合征 认知障碍特点 中医证候 

分 类 号：R277.7[医药卫生—中医学]