糖平煎对2型糖尿病大鼠血清游离脂肪酸、瘦素、白介素-6和肿瘤坏死因子-α的影响  

Effects of Tangpingjian on serum free fatty acid,leptin,interleukin-6 and tumor necrosis factor-alpha in rats with type 2 diabetes mellitus

作　　者：张永鹏[1] 刘静 罗飞[1] 朱峰[1] 张海霞[1] 张秀琴[1] 李永民[1] 

机构地区：[1]河北北方学院,张家口075000 [2]张家口市中心血站,张家口075000

出　　处：《中华中医药杂志》2012年第2期382-384,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省科技厅项目(No.022761217);张家口市科技局项目(No.1012011D-3)~~

摘　　要：目的:观察糖平煎对2型糖尿病(T2DM)大鼠血清游离脂肪酸(FFA)、瘦素(Leptin)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法:采取高热量饲料喂养结合小剂量链脲佐菌素(STZ)腹腔注射的方法复制T2DM大鼠模型,随机分为对照组、模型组及糖平煎大(HTPJ组)、小剂量组(LTPJ组),连续治疗4周。观察大鼠血清FFA、Leptin、IL-6和TNF-α水平的变化。结果:糖平煎能明显降低血清FFA、Leptin、IL-6、TNF-α,与模型组比较有显著性差异(P<0.05,P<0.01)。结论:糖平煎可以改善T2DM大鼠脂毒性,降低血清炎症因子(Leptin,IL-6,TNF-α)的水平,这可能是其影响机体脂代谢过程,改善胰岛素抵抗(IR)的机制之一。Objective： Observing the effects of Tangpingjian（TPJ） on serum free fatty acid（FFA）,leptin,interleukin-6（IL-6） and tumor necrosis factor-alpha（TNF-α） in rats with type 2 diabetes mellitus（T2DM）.Methods： Reconstructing the T2DM rat model by adopting the method of feeding them with high calorie forage combined with low-dose streptozotocin（STZ） intraperitoneal injection.The rats were divided into four groups： normal control group,model control group,high-dose TPJ group and low-dose TPJ group.Then they were given successive treating with TPJ for 4 weeks,and the serum FFA,leptin,IL-6 and TNF-α of rats were measured.Results： TPJ could decrease serum FFA,leptin,IL-6 and TNF-α remarkably in experimental rats,and it had significant differences compared with model group（P0.01,P0.05）.Conclusion： TPJ can decrease lipid toxicity in the rats and reduce the level of serum inflammation factors（Leptin,TNF-a,IL-6）,which might be one of its mechanisms that it has effects on the process of body fat metabolism and improvement of insulin resistance（IR）.

关 键 词：游离脂肪酸 瘦素 白介素-6 肿瘤坏死因子-α 糖平煎 胰岛素抵抗 

分 类 号：R285.5[医药卫生—中药学]