缺氧缺血性脑病新生儿血清心肌肌钙蛋白I及脑型肌酸激酶同工酶的变化及临床意义  

Changes and clinical significance of serum cardiac troponin and creatine kinaes BB isozyme in newborns with hypoxic-ischemic encephalopathy

作　　者：潘燕峰 张桂欣 

机构地区：[1]驻马店市第一人民医院新生儿科,河南驻马店463000

出　　处：《新乡医学院学报》2012年第2期111-112,115,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨新生儿缺氧缺血性脑病(HIE)早期血清脑型肌酸激酶同工酶(CK-BB)及心肌肌钙蛋白I(cTnI)水平的变化及临床意义。方法 106例HIE新生儿(HIE组)于出生后24 h测定血清CK-BB及cTnI水平,并与同期36例健康新生儿(对照组)进行比较。结果中、重度HIE患儿出生后24 h血清CK-BB及cTnI水平高于对照组(P<0.01);轻度HIE患儿血清CK-BB水平高于对照组(P<0.05),但cTnI水平比较差异无统计学意义(P>0.05);轻、中、重度HIE患儿之间CK-BB及cTnI水平比较差异均有统计学意义(P<0.01)。出生7、14 d时,新生儿行为神经(NBNA)评分<35的HIE新生儿血清CK-BB、cTnI水平均高于NBNA评分≥35者(P<0.01)。结论 HIE新生儿出生后24 h检测CK-BB及cTnI水平有助于评估HIE严重程度及患儿预后。Objective To study the changes and clinical significance of serum cardiac troponin（cTnI） and creatine kinaes BB isozyme（CK-BB） in newborns with hypoxic-ischemic encephalopathy（HIE）.Methods The levels of cTnI and CK-BB in one hundred and six newborns with HIE（HIE group） and thirty-six healthy newborns（control group） were detected and comparison twenty-four hours after birth.Results The levels of serum cTnI and CK-BB in newborns with midrange and severe HIE twenty-four hours after birth were higher than those in control group（P0.01）.The level of serum CK-BB in newborns with mild HIE was higher than that in control group（P0.05）,but there was no significant difference in the level of cTnI between two groups（P0.05）.There were significant difference in the levels of serum cTnI and CK-BB among the newborns with mild,midrange and severe HIE（P0.01）.Seven and fourteen days after birth,the levels of serum cTnI and CK-BB in the newborns with NBNA score 35 points were higher than those in the newborns with neanatal behavioral neurological assessment（NBNA） score ≥35 points（P0.01）.Conclusion The levels of serum cTnI and CK-BB detection twenty-four hours after birth can be helpful to evaluate the severity of HIE and prognosis of newborns.

关 键 词：缺氧缺血性脑病 新生儿 脑型肌酸激酶同工酶 心肌肌钙蛋白 

分 类 号：R722[医药卫生—儿科]