彩虹明樱蛤多糖对小鼠急性化学性肝损伤的保护作用  

Protective effect of Moerella iridescens polysaccharide on acute liver injury of mice

作　　者：向维[1,2] 陈松华[1] 李朝品[2] 

机构地区：[1]中国人民解放军南京军区南京总医院疗养区(全军医学康复中心),江苏南京211131 [2]皖南医学院病原生物学教研室,安徽芜湖241002

出　　处：《中国生化药物杂志》2012年第1期43-45,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家自然科学基金项目(No 30872367)

摘　　要：目的研究彩虹明樱蛤多糖(MIP)对CCl4致小鼠急性化学性肝损伤的保护作用。方法 MIP对小鼠连续腹腔注射7 d,以0.1%CCl4橄榄油溶液经腹腔注射,建立小鼠急性化学性肝损伤模型,测定给药后模型小鼠肝指数,检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性,测定肝组织匀浆中丙二醛(MDA)含量和超氧化物歧化酶(SOD)、谷胱甘肽(GSH)的活性及观察肝脏病理学变化。结果 MIP中、高剂量组(80,160 mg/kg)均能显著降低CCl4致急性肝损伤小鼠血清ALT、AST活性(P<0.01),降低肝脏MDA含量(P<0.01),增强SOD和GSH活力(P<0.01或0.05),并能明显改善肝组织的病理学损伤,但对肝指数无明显影响。结论 MIP对CCl4致小鼠急性化学性肝损伤有保护作用。Purpose To study the protective effect of Moerella iridescens polysaccharide （MIP）on CC14-induced acute liver injury in mice. Methods The mice were treated with MIP via intraperitoneal in- jection for 7 days before CC14 treatment. The activities of serum alanine aminotransferase （ALT） and as- partate aminotransferase （AST） , liver index and malondialdehyde （MDA） , hepatic superoxide dismutase （SOD） and glutathione（GSH） , as well as the pathological changes of the liver were determined in all groups. Results The middle（80 mg/kg） and the high（ 160 mg/kg） doses could significantly decrease se- rum ALT and AST（P 〈 0.01 ） ,lower the content of MDA in the liver（P 〈 0.01 ）, increase hepatic SOD and MDA（ P 〈0.01 ,P;〈 O. 05 ） , and improve the liver histology. Htowever it had no influence on the liver index of mice. Conclusion MIP has protective effects on acute hepatic injury induced by CC14 in mice.

关 键 词：彩虹明樱蛤多糖 四氯化碳 急性肝损伤 

分 类 号：R285[医药卫生—中药学]