不同透析膜对血透患者血清C反应蛋白、白细胞介素-6、白细胞介素-8和白蛋白的影响，  

The effects of different hemodialysis membrane on the levels of serum CRP, IL-6, IL-8 and albu- min in hemodialysis patients

作　　者：田津生[1] 张怡静[2] 

机构地区：[1]河北省保定市第二医院,071000 [2]河北省保定市第三医院

出　　处：《临床内科杂志》2012年第1期40-42,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨不同透析膜对维持性血液透析（MHD）患者血清C反应蛋白（CRP）、自细胞介素（IL）-6、白细胞介素-8和白蛋白（ALB）水平的影响。方法选取维持性血液透析患者54例，随机分为纤维素膜组、聚砜膜F6组和聚砜膜F60组3组，每组18例。监测3组患者治疗前后C反应蛋白、白细胞介素_6、白细胞介素-8和白蛋白水平的变化，30例健康体检者作为对照组。结果维持性血液透析患者透析前C-反应蛋白、白细胞介素-6及白细胞介素-8水平均高于对照组（P〈0．01），白蛋白水平低于对照组（P〈0．01）。纤维素膜组单次透析后C反应蛋白、白细胞介素-6及白细胞介素-8水平上升（P〈0．01），聚砜膜F6组及聚砜膜F60组单次透析后C反应蛋白、白细胞介素-6及白细胞介素-8水平无明显变化（P〉0．05）；聚砜膜F60组治疗8个月后C反应蛋白、白细胞介素-6及白细胞介素-8水平下降（P〈0．01），白蛋白水平上升（P〈0．05），纤维素膜组及聚砜膜F6组治疗8个月后c反应蛋白、白细胞介素-6、白细胞介素-8及白蛋白水平无明显变化（P〉0．05）。结论维持性血液透析患者存在微炎症状态，这种炎症状态与透析膜的生物相容性有关，高通量合成膜能改善维持性血液透析患者的微炎症状态。Objective To investigate the effect of different hemodialysis membrane on the levels of serum CRP, IL-6, IL-8 and albumin in maintenance hemodialysis （MHD） patients. Methods Fifty-four MHD patients were randomly divided into triacetate membrane group ,polysuIfone membrane F6 group and polysulfone membrane F60 group. The concentrations of serum CRP, IL-6, IL-8 and ALB were detected. 30 healthy people as the normal control group. Results The concentrations of CRP, IL-6 and IL-8 in patients of MHD group before statin treatment were much higher than those in normal control group, and meanwhile the concentrations of plasma ALB were significantly lower than those in normal control group. The concen- trations of CRP,IL-6 and IL-8 increased significantly in patients of triacetate membrane group after the First hemodialysis therapy. The concentrations of CRP, IL-6 and IL-8 didn＇ t change significantly in pa- tients of polysuffone membrane F6 group and polysulfone membrane F60 group after the First bemodialysis therapy. The concentrations of CRP, IL-6 and IL-8 decreased significantly in patients of polysuIfone mem- brane F60 group after being treated with hemodialysis therapy for 8 months, and the concentrations of plas- ma ALB increased significantly after being treated with hemodialysis therapy for 8 months. The concentra- tions of CRP,IL-6,IL-8 and ALB didnt change significantly in patients of triacetate membrane group and polysulfone membrane F6 group after being treated with hemodialysis therapy for 8 months. Conclusion A microinflammatory state develops in MHD patients and is associated with the biocompatibility of different hemodialysis membranes. The microinflammation in MHD patients can be inhibited effectively by high flux hemodialysis membrane therapy.

关 键 词：血液透析 透析膜 生物相容性 微炎症状态 

分 类 号：R459.5[医药卫生—治疗学]