维生素D及其受体对3T3-L1前脂肪细胞分化影响的分子机制  

The Molecular Mechanism of Vitamin D and Its Receptors Inhibiting 3T3-L1 Preadipocyte Differentiation

作　　者：张力翔[1] 缪珩[1] 

机构地区：[1]南京医科大学第二附属医院内分泌科,南京210011

出　　处：《医学综述》2012年第3期336-338,共3页Medical Recapitulate

摘　　要：前脂肪细胞增殖、分化过度是肥胖的一个重要病理机制。早在20多年前就已发现维生素D可以抑制3T3-L1前脂肪细胞系分化成熟,相关的分子机制近几年有了新的进展。3T3-L1分化是一个受多种基因蛋白调节的具有严格时序性的过程,现已证实维生素D与其受体结合后作用于3T3-L1分化早期的分子事件,如减少PPARγ配体形成,减少CCAAT/增强子结合蛋白βmRNA的表达,抑制C/EBPβ的转录活性,同时也作用于晚期分子事件,如抑制C/EBPα和PPARγ的mRNA表达等,通过影响这些重要分子发挥其抑制作用。One important pathology of obesity is the hyperproliferation and overdifferentiation of preadipocytes.The fact that vitamin D inhibits the differentiation of 3T3-L1 preadipocytes is known for more than twenty years.Until recent years,researchers found that vitamin D3 could inhibit some important genes and proteins which played key role during differentiation,such as reducing PPARr ligands,inhibting C/EBPβ transcriptionl activity,and inhibiting the mRNA expression of C/EBPα,CCAAT/enhancer binding proteinβ and PPARγ.With all these foundings,the main underlying mechanism is getting clearer.

关 键 词：维生素D 维生素D受体 3T3-L1细胞 细胞分化 

分 类 号：R589[医药卫生—内分泌]