汉族人群蛋白C、蛋白S和抗凝血酶活性水平及活性缺乏发生率的研究  

The activity levels and prevalence of deficiency of protein C, protein S and antithrombin in Chinese Han population

作　　者：朱铁楠[1] 赵永强[1] 丁秋兰[2] 白霞 王晓燕[1] 王学锋[2] 杨仁池[3] 王兆钺 华宝来[1] 魏旭倩[2] 阮长耿 Nicole Schlegel 

机构地区：[1]中国医学科学院、北京协和医学院北京协和医院血液内科,北京100730 [2]上海交通大学医学院附属瑞金医院、上海血液学研究所 [3]中国医学科学院、北京协和医学院血液学研究所、血液病医院 [4]苏州l大学附属第一医院、江苏省血液研究所 [5]法国巴黎RobertDebr6医院

出　　处：《中华血液学杂志》2012年第2期127-130,共4页Chinese Journal of Hematology

基　　金：法国DiagnosticaStago科研基金

摘　　要：目的探讨蛋白C（PC）、蛋白S（PS）和抗凝血酶（AT）活性水平在中国汉族健康人群中的分布及其影响因素，观察此3种天然抗凝蛋白缺乏的发生率。方法国内四家医学中心参加此研究，采集汉族健康献血员或常规体检者的外周静脉血标本，分别测定血浆PC、AT和PS的活性，前两者采用发色底物法，后者采用凝固法。结果共募集3493名汉族志愿者。女性人群血浆PS和PC活性低于男性人群，以PS活性尤为显著（P〈0．01）；PC活性在不同性别人群均随年龄增长而增加，但在50岁后的男性人群中则呈下降趋势；PS活性在50岁前的人群中随年龄的变化不明显，但在50岁后的男性和女性人群中分别呈下降和上升趋势；AT活性在女性人群随年龄增长而逐步增加，而在50岁后男性人群明显下降。根据年龄和性别，PC、PS和AT缺乏的总发生率分别为1．15％、1．49％和2．29％。结论在中国汉族健康人群中，PC、PS和AT的活性水平受年龄和性别的影响明显，应根据年龄和性别制定参考值范围和判断是否存在活性缺陷。Objective To explore the distribution and infuence factors of protein C （PC）, protein S （P S） and antithombin （AT） activities and to determine the prevalence of their deficiencies in the Chinese Han healthy population. Methods Healthy volunteers including blood donors and individuals for routine check-up were recruited from 4 Chinese medical centers. The plasma levels of PC, PS and AT activities were measured. The plasma levels of activities were measured by chromogenic substrate assay （ AT and PC） and clotting assay （PS）. Results A total of 3493 healthy Chinese adults had been recruited in this study. Males had higher PS and PC activities than females, especially for PS （P 〈 0.01 ）. PC activities increased with age in both sexes but decreased in men after 50 years old. There was no significant change with age were of PS in 50 years old, while there was a decline in males and a rise in females above 50 years old. AT tended to in- crease with age in women but decreased with age in men after 50 years old. Based on the age and gender, the general prevalence of PC, PS and AT deficiencies in the general Chinese Han population were 1. 15% , 1.49% and 2.29% , respectively. Conclusion PC, PS and AT activities have correlation with age and gen- der in Chinese Han poputation. Reference range should be laid down and deficiencies should be identified based on age and gender.

关 键 词：蛋白C 蛋白S 抗凝血酶 

分 类 号：R55[医药卫生—血液循环系统疾病]