来氟米特治疗儿童频复发型肾病综合征的临床观察  

Leflunomide for idiopathic frequent-relapsing nephrotic syndrome in children

作　　者：王自良[1] 王明波[1] 刘鹏[1] 袁明良[1] 

机构地区：[1]山东省莱芜市人民医院肾内科,271127

出　　处：《临床肾脏病杂志》2012年第1期24-25,共2页Journal Of Clinical Nephrology

摘　　要：目的 观察来氟米特对儿童频复发型肾病综合征治疗效果.方法 选择31例频复发型肾病综合征患儿,其中微小病变（MCD） 18例,局灶节段性肾小球硬化（FSGS） 13例,给予来氟米特治疗.结果 来氟米特治疗后,泼尼松隔日应用维持量从（0.58±0.19） mg/kg减少至（0.21±0.25）mg/kg,复发率从平均每年（3.10±0.88）次下降至平均每年（1.00±1.18）次.其中有10例患儿泼尼松停止应用而没出现复发.结论 来氟米特在治疗儿童频复发型肾病综合征方面是有效的.Objective To observe the efficacy of Leflunomide in the treatment of idiopathic frequent-relapsing nephrotic syndrome. Methods Thirty-one children with idiopathic frequent-relapsing nephrotic syndrome （18 with minimal change disease, and 13 with focal segmental glomerulosclerosis） were enrolled in this study. All of them were given Leflunomide. Results Treatment with Leflunomide resulted in a reduction of mean minimum prednisolone dose from（0. 58 ± 0. 19）to （0. 21 ±0. 25 ） mg/kg on alternate days （P〈0. 01）, and the median relapse rate from （3. 10± 11. 88） to （ 1.00 ± 1.18） episodes/one year （P〈0. 01）. Of them, prednisolone could be withdrawn in 10 patients without relapse of nephritic syndrome. Conclusions Our experience demonstrates that Leflunomide may be effective in children with idiopathic frequent-relapsing nephrotic syndrome.

关 键 词：来氟米特 肾病综合征 儿童 

分 类 号：R692.05[医药卫生—泌尿科学]