Association between AKT1 gene polymorphisms and depressive symptoms in the Chinese Han population with major depressive disorder  

作　　者：Chunxia Yang Ning Sun Yan Ren Yan Sun Yong Xu Aiping Li Kewen Wu Kerang Zhang 

机构地区：[1]First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China [2]Department of Psychiatry, Three Hospital of Shanxi Medical University, Taiyuan 030053, Shanxi Province, China [3]Rongjun Kangning Psychiatric Hospital of Shanxi Province, Taigu 030800, Shanxi Province, China

出　　处：《Neural Regeneration Research》2012年第3期235-239,共5页中国神经再生研究（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China, No. 30770770,30971054;Personnel Returned Overseas Research Foundation of Shanxi Province, No. 2007-48;Science Foundation for Youths of Shanxi Province, No. 2010021036-3;the Special Fund Talent of Shanxi Province, Foundation for Youths of Shanxi Province, No. 2011021036-1

摘　　要：For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score, four factors and the AKT1 rs2494746 and rs3001371 polymorphisms. The results indicate that there is a significant association between suicidal ideation and anxiety symptoms in depressed patients and the rs2494746 polymorphism. The other AKT1 polymorphism, rs3001371, was significantly associated with work and activities. Patients with the rs3001371-A allele had a significantly more severe illness compared to patients with the rs3001371-G allele. Thus, AKT1 polymorphisms appear to be associated with depression severity, anxiety symptoms, work and activities, and suicide attempts in patients with depressive disorder.For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score, four factors and the AKT1 rs2494746 and rs3001371 polymorphisms. The results indicate that there is a significant association between suicidal ideation and anxiety symptoms in depressed patients and the rs2494746 polymorphism. The other AKT1 polymorphism, rs3001371, was significantly associated with work and activities. Patients with the rs3001371-A allele had a significantly more severe illness compared to patients with the rs3001371-G allele. Thus, AKT1 polymorphisms appear to be associated with depression severity, anxiety symptoms, work and activities, and suicide attempts in patients with depressive disorder.

关 键 词：AKT1 major depression SYMPTOMS POLYMORPHISM neural regeneration 

分 类 号：Q346.5[生物学—遗传学] Q347