代谢综合征与脑梗死患者早期预后关系的研究  

Study on the Relationship of Early Prognosis between Metabolic Syndrome in Patients with Cerebral Infarction

作　　者：王晓强 张淑伟 康爱红 田笑君 

机构地区：[1]河北省承德市双滦区医院神经内科,067001

出　　处：《中国全科医学》2012年第3期245-248,共4页Chinese General Practice

摘　　要：目的研究代谢综合征(MS)与脑梗死患者的早期预后关系。方法选取我院2009年1月—2011年11月收治的脑梗死患者258例,按照是否合并MS,将患者分为脑梗死合并MS组(MS组,134例)和脑梗死无MS组(非MS组,124例)。观察两组梗死灶的数量、梗死面积和颅内血管狭窄的程度,并分别评定治疗第1、14及28天的临床神经功能缺损程度及治疗第28天的临床疗效。结果 258例脑梗死患者中,≤50岁组MS 10例(33.5%),51～60岁组MS 27例(40.9%),≥61岁组MS 97例(59.5%),经关联性趋势统计分析,脑梗死患者随着年龄的增长MS发病率有增加趋势(P<0.01)。治疗后第1、14、28天,MS组患者临床神经功能缺损评分均显著高于非MS组,差异有统计学意义(P<0.05)。MS组脑梗死患者大梗死灶发生率及多灶梗死发生率显著高于非MS组,而腔隙性梗死发生率显著低于非MS组,差异有统计学意义(P<0.05)。MS组患者颅内血管狭窄程度较非MS组重,差异有统计学意义(P<0.01)。治疗第28天,非MS组和MS组患者总有效率比较(75.0%与55.9%),差异有统计学意义(P<0.01)。结论脑梗死患者合并MS随年龄增长有增加趋势;与单纯性脑梗死患者比较,脑梗死合并MS患者的临床神经功能缺损程度加重,大灶梗死、多灶梗死率高,腔隙梗死率低,颅内血管狭窄程度重,早期预后差。Objective To study the relationship of early prognosis between metabolic syndrome（MS）in the patients with cerebral infarction.Methods 258 patients who had cerebral infarction from Jan.2009 to Nov.2011 in our hospital were selected,which were divided into two groups according to whether they had MS or not,the group 134 patients with cerebral infarction complicated with metabolic syndrome（n=134） and the other group 124 patients without metabolic syndrome（n=124）.The number of cerebral infarction,the area of cerebral infarction and stenoses of the large intracerebral vessels were observed between two groups,separately to judge the degree of the clinical neurological deficit scores in 1,14,and 28 days and appraise the clinical prognosis in the 28 days after the incidence.Results Among 258 patients,10 patients（33.5%） with MS in ≤50 group,27 patients（40.9%） with MS in 51~60 group,97 patients（59.5%） with MS in ≥61 group,the statistical analysis of the trend of relevance,cerebral infarction with the growth as the age MS incidence is increasing trend（P0.01）.After 1,14,and 28 days,the clinical neurological deficit scores of MS group was higher than non-MS group,the difference was significant（P0.05）.The incidence rate of the large cerebral infarction and multiple infarction are higher than the latter,while the lacunar infarction is lower（P0.05）.The total effective rate was higher in non-MS group than MS group in the 28 days（75.0% vs 55.9%,P0.01）,the stenoses of the large intracerebral vessels is more serious than the former.Conclusion Cerebral infarction with the growth as the age MS incidence is increasing trend,the clinical neurological deficit scores is more serious than patients without MS,the large cerebral infarction and multiple infarction are higher than the latter,while the lacunar infarction is lower,and stenoses of the large intracerebral vessels is more serious than without metabolic syndrome,the efficacy of early prognosis is worse than the former.

关 键 词：代谢综合征X 脑梗死 预后 

分 类 号：R589[医药卫生—内分泌] R743.33[医药卫生—内科学]