天门市第一人民医院抗菌药物临床应用分析  

Clinical Application of Antibiotics in Tianmen Municipal First People's Hospital

作　　者：曾祥平[1] 王杏娥[1] 

机构地区：[1]天门市第一人民医院药剂科,湖北天门417300

出　　处：《中国医院用药评价与分析》2012年第1期14-16,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:分析我院抗菌药物使用情况,为临床合理用药提供依据。方法:以随机抽样法抽取我院2011年1—6月门诊处方4 216份和住院病历420份,对抗菌药物使用情况进行统计分析。结果:门诊抗菌药物使用率为34.1%(1 437/4 216);住院患者抗菌药物使用率为70.0%(294/420),合理用药率为68.1%(286/420),标本送检率为53.3%(224/420);限定日费用(DDC)排序后5位是司帕沙星、红霉素、加替沙星、克拉霉素、氨苄西林丙磺舒,都是口服类药;住院患者用药频度(DDDs)排序前5位是头孢哌酮/舒巴坦、头孢噻吩、美洛西林、头孢唑林、头孢呋辛;其中药物利用指数(DUI)排序前4位:头孢替唑>克林霉素>美洛西林>左氧氟沙星>1。抗菌药物使用强度为53.3 DDD,明显高于规定的40 DDD。结论:我院抗菌药物的应用总体趋于合理,但存在一些不合理现象,仍需要加强对抗菌药物合理使用的监测,促进合理用药。OBJECTIVE： To analyze the use of antibiotics in the patients of our hospital to provide references for clinical rational use of antibiotics. METHODS ： 4 216 outpatient prescriptions and 420 medical records in the first half year of 2011 were sampled randomly for statistical analysis of the antibiotic use. RESULTS ： The rate of antibiotic use in outpatients was 34. 1% （1 437/4 216） ; in the inpatients, the rate of antibiotic use was 70.0% （294/420）, with the rate of rational drug use of 68.1% （286/420） and the rate of specimen test of 53.3% （224/420）. The antibiotics ranked among the last 5 places in respect of DDC were sparfloxacin, erythromycin, gatifloxacin, clarithromycin and ampicillin/probenecid, with all administered orally. The top five antibiotics in terms of DDDs for inpatients were cefoperazone/sulbactam, cefalotin, mezlocilhn, cephazolin and cefuroxime. The top 4 antibiotics ranked by DUI in descending order were ceftezole 〉 clindamycin 〉 mezlocillin 〉 levofloxacin 〉 1. The total antibiotic use density which stood at 53.3 DDD was significantly higher than the specified value of 40 DDD. CONCLUSION ： The use of antibiotics in our hospital was basically rational yet far from perfect, thus it is urgent to tighten monitoring the use of antibiotics to promote clinical rational use antibiotics.

关 键 词：抗菌药物 药物利用指数 用药分析 使用强度 

分 类 号：R978.1[医药卫生—药品]