非诺贝特对高甘油三酯血症并骨质疏松大鼠骨代谢的影响  

Effects of fenofibrate on bone metabolism of hyper-triglyceride with osteoporosis rats

作　　者：曾炼坤[1] 刘雪芳[1] 邱丽浈[1] 李万根[2] 邓煜辉[2] 夏碧文[1] 

机构地区：[1]中山大学附属第二医院增城院区内分泌科,广东广州511300 [2]广州医学院第二附属医院内分泌科,广东广州510260

出　　处：《热带医学杂志》2012年第1期34-36,共3页Journal of Tropical Medicine

摘　　要：目的探讨非诺贝特对去卵巢骨质疏松并高甘油三酯(TG)血症大鼠股骨中细胞核因子κB受体活化因子配体/护骨素(RANKL/OPG)mRNA表达的影响。方法将40只3月龄雌性SD大鼠,用果糖饲养复制高TG模型,大鼠共分为去卵巢+果糖组、去卵巢+果糖+非诺贝特(FF)组、去卵巢+普食组、假手术+果糖组。12周后取股骨检测细胞核因子κB受体活化因子配体(RANKL)mRNA、护骨素(OPG)mRNA表达水平。结果去卵巢+果糖组的TG水平高于去卵巢+普食组(P<0.01),也高于去卵巢+果糖+FF组(P﹤0.01);去卵巢+果糖组RANKL mRNA/OPG mRNA水平,均高于去卵巢+果糖+FF组、去卵巢+普食组和假手术+果糖组(P<0.01或<0.05)。结论非诺贝特可通过降低TG而保持RANKLmRNA/OPGmRNA的平衡。Objective To investigate the effects of fenofibrate on the expression of osteoprotegerin（OPG）,receptor activator of nuclearfator-κB ligand（RANKL） in ovariectomized rats. Methods Forty female SD rats were randomly divided into 4 groups： ovariectomy ＋ fructose（OVX＋FO）,ovariectomy ＋ fructose ＋fenofibrate（OVX＋FO＋FF）,ovariectomy ＋normal diet（OVX＋ND）,sham operation ＋ fructose（Sham＋FO）. Twelve weeks after operation, all rats were sacrificed and right femora were collected. Then OPG mRNA and RANKL mRNA expression were tested and analysed by RT-PCR. Result Fenofibrate up-regulated the expression of OPG but down-regulated RANKL expression in femoral of rats. Conclusions Hypertriglyceridemia can lead to down-regulate of OPG mRNA and up-regulate RANKL mRNA on the femoral bone in ovariectomized rats. Fenofibrate can prevent the adverse effect.

关 键 词：高甘油三酯血症 去卵巢大鼠 护骨素 细胞核因子κB受体活化因子配体 

分 类 号：R589.9[医药卫生—内分泌]