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作 者:胡小亮[1] 路方红[1] 刘振东[1] 赵颖馨[1] 孙尚文[1] 王舒健[1] 潘慧[1] 李俊[1]
出 处:《中国动脉硬化杂志》2012年第2期145-148,共4页Chinese Journal of Arteriosclerosis
基 金:山东省自然科学基金项目(ZR2009CL029);山东省医药卫生计划项目(2009HW080);山东省医学科学院项目[2009(16);(17);2010(13)]
摘 要:目的探讨血压正常高值者动脉僵硬度与动态血压参数的关系。方法选择理想血压者63例,血压正常高值者74例,高血压者67例。监测所有入选者24 h动态血压,应用脉搏波传导速度测定仪测定颈动脉-桡动脉脉搏波传导速度。结果血压正常高值组24 h收缩压、24 h舒张压、白昼收缩压、白昼舒张压、夜间收缩压、24 h脉压、白昼脉压及夜间脉压均高于理想血压组,低于高血压组(P<0.05或P<0.01);血压正常高值组夜间舒张压低于高血压组(P<0.05)。血压正常高值组颈动脉-桡动脉脉搏波传导速度(9.67±1.12 m/s)显著高于血压理想组(8.27±0.99 m/s),低于高血压组(10.55±1.71 m/s;P<0.05或P<0.01)。多元线性回归分析显示,24 h收缩压、24 h脉压、夜间收缩压是颈动脉-桡动脉脉搏波传导速度的影响因素(β值分别为0.385、0.351及0.247,P<0.05)。结论血压正常高值者动脉僵硬度增高,24 h收缩压、24 h脉压、夜间收缩压是影响动脉弹性的主要因素。Aim To investigate the relationship between ambulatory blood pressure parameters and arterial stiffness in prehypertensive patients. Methods According to their blood pressure level,204 individuals were divided into three groups: namely normotensive controls(n=63),prehypertensive participants(n=74) and hypertensive patients(n=67).The 24 h ambulatory blood pressure monitoring was used to record 24 h systolic blood pressure(24h SBP),24 h diastolic blood pressure(24h DBP),daytime systolic blood pressure(dSBP),daytime diastolic blood pressure(dDBP),nighttime systolic blood pressure(nSBP),nighttime diastolic blood pressure(nDBP),24 h pulse pressure(24h PP),daytime pulse pressure(dPP) and nighttime pulse pressure(nPP).Carotid-radial pulse wave velocity(crPWV) was obtained by Complior device. Results 24h SBP,24h DBP,dSBP,dDBP,nSBP,24h PP,dPP and nPP were higher in prehypertensive than those in normotensives,but lower in hypertensives(P〈0.05 or P0.01).The crPWV in prehypertensives was 9.67±1.12 m/s,which was higher than that in normotensives(8.27±0.99 m/s),but was lower in hypertensives(10.55±1.71 m/s).Multiple linear regression analysis showed that 24h SBP,24h PP and nSBP were risk factors for crPWV(β=0.385,0351 and 0.247;all P〈0.05). Conclusion Arterial stiffness had been increased in prehypertensives.24h SBP,24h PP and nSBP are the important influencing factors of arterial stiffness.
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