不同糖代谢状况患者血浆生长停滞特异性基因产物6水平与高敏C反应蛋白、内脂素、脉搏波传导速度和踝肱指数的关系  

Correlation Between Plasma Growth Arrest-specific Gene 6 Level and High Sensitivity C-reactive Protein,Visfatin,Pulse Wave Velocity and Ankle Brachial Index in Patients with Different Glucose Metabolic Status

作　　者：高宁[1] 陈少华[1] 张伟[1] 王焕君[1] 

机构地区：[1]山东大学附属千佛山医院内分泌科,山东省济南市250014

出　　处：《中国动脉硬化杂志》2012年第2期161-165,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨不同糖代谢状况患者血浆生长停滞特异性基因产物6水平变化及其与高敏C反应蛋白、内脂素、脉搏波传导速度及踝肱指数等的关系。方法采用酶联免疫吸附法检测2型糖尿病合并下肢动脉疾病、2型糖尿病、糖调节受损和正常糖耐量患者血浆生长停滞特异性基因产物6、内脂素水平;动脉硬化检测仪检测脉搏波传导速度和踝肱指数。结果 2型糖尿病合并下肢动脉疾病组血浆生长停滞特异性基因产物6低于2型糖尿病组(P<0.05),2型糖尿病组血浆生长停滞特异性基因产物6显著低于正常糖耐量组(P<0.01)。Pearson相关分析表明,血浆生长停滞特异性基因产物6与年龄、病程、空腹血糖、糖负荷后2 h血糖、糖化血红蛋白、腰臀比、内脂素、高敏C反应蛋白、脉搏波传导速度均呈负相关(P<0.01或P<0.05),与踝肱指数呈正相关(P<0.01)。多元逐步回归分析显示,腰臀比、糖化血红蛋白、高敏C反应蛋白与血浆生长停滞特异性基因产物6独立相关。结论血浆生长停滞特异性基因产物6在糖调节受损期有所下降,在糖尿病及并发下肢动脉疾病中显著降低,与炎症、周围血管动脉粥样硬化及内脏脂肪有关,可能是糖尿病的一个独立危险因子。Aim To investigate the change of plasma growth arrest-specific gene 6（Gas6） level and the relationship of plasma Gas6 level to high sensitivity C-reactive protein（hs-CRP）,visfatin,the pulse wave velocity（PWV）,and the ankle brachial index（ABI） in the patients with different glucose metabolic status. Methods Plasma Gas6 and visfatin level were assayed by enzyme-linked immunosorbent assay in type 2 diabetic patients with lower extremity artery diseases（T2DM-LEAD）,type 2 diabetic patients（T2DM）,patients with impaired glucose regulation（IGR） and normal glucose tolerance（NGT）.PWV and ABI were tested by the non-invasive vascular screening device. Results Plasma Gas6 level in T2DM-LEAD group was lower than that in T2DM group（P〈0.05）,and it was significantly reduced in T2DM group compared with NGT group（P〈0.01）.Pearson＇s correlation analysis demonstrated that plasma Gas6 level was negatively correlated with age,duration of diabetes,fasting plasma glucose,2 h plasma glucose after glucose loading,glycosylated hemoglobin（HbA1c）,waist to hip ratio,visfatin,hs-CRP and PWV（P〈0.01 or P〈0.05）,and positively correlated with ABI（P〈0.01）.Multiple stepwise regression analysis showed waist to hip ratio,HbA1c and hs-CRP were independently related with plasma Gas6 level. Conclusions The plasma Gas6 level is lower in patients with IGR,and is significantly reduced in patients with T2DM and T2DM-LEAD.The change of Gas6 level is associated with inflammation,peripheral vessels atherosclerosis and visceral fat,which may be a potential risk factor of diabetes mellitus.

关 键 词：生长停滞特异性基因产物6 内脂素 2型糖尿病 糖调节受损 下肢动脉疾病 

分 类 号：R5[医药卫生—内科学]