巨噬细胞移动抑制因子对2型糖尿病患者血管病变的影响  

Effect of serum macrophage migration inhibitory factor on type-2 diabetes-related angiopathy

作　　者：倪正平[1] 张建[2] 巴荣[2] 雷艳花[2] 金星进[3] 王建娟[3] 陆益龙[2] 

机构地区：[1]丹阳市人民医院内科,江苏省212300 [2]江苏大学附属医院 [3]南通大学附属妇幼保健院内科

出　　处：《江苏医药》2012年第3期275-277,共3页Jiangsu Medical Journal

基　　金：南通市社会发展基金项目(S2007023)

摘　　要：目的探讨2型糖尿病(T2DM)患者血清巨噬细胞移动抑制因子(MIF)水平变化及其对糖尿病血管病变的影响。方法用ELISA法检测T2DM合并血管病变患者(A组,19例)、T2DM无血管病变患者(B组,19例)和健康体检者(C组,16例)血清MIF和超敏C反应蛋白(hs-CRP)。同时检测血糖(BG)和糖化血红蛋白(HbA1c)。结果 A组和B组MIF、hs-CRP水平均高于C组(P<0.01)。A组hs-CRP与血糖呈正相关。B组MIF与hs-CRP、BG水平呈正相关,hs-CRP与BG、HbA1c水平呈正相关。结论糖尿病血管病变患者MIF与hs-CRP高表达是促进血管病变发生的重要因素。Objective To investigate the changes of the serum contents of macrophage migration inhibitory factor（MIF） and its effect on the development of angiopathy in the patients with type-2 diabetes mellitus（T2DM）.Methods Serum MIF and high-sensitivity C-reactive protein（hs-CRP） were detected with ELISA in 19 T2DM cases with angiopathy（group A）and 19 T2DM without angiopathy（group B） and 16 healthy persons（group C）.The contents of blood glucose（BG） and glycosylated hemoglobin A-1c（HbA1c） were tested as well.Results Serum levels of MIF and hs-CRP were higher in groups of A and B than those in group C.Serum hs-CRP was positively correlated to BG in group A.Serum MIF was positively correlated to hs-CRP and BG,and hs-CRP was positively correlated with BG and HbA1c in group B.Conclusion High expressions of MIF and hs-CRP are the important factors to promote the development of angiopathy in the patients with T2DM.

关 键 词：2型糖尿病 糖尿病血管病变 巨噬细胞移动抑制因子 超敏C反应蛋白 

分 类 号：R587[医药卫生—内分泌]