依帕司他与甲钴胺联合治疗糖尿病周围神经病变疗效的Meta分析  

Effects of epalrestat combined with methylcobalamin on diabetic peripheral neuropathy:a Meta-analysis

作　　者：阮园[1] 马建华[1] 谢晓竞[1] 郭宁[1] 王敏[1] 

机构地区：[1]南京医科大学附属南京第一医院内分泌病科,江苏省210006

出　　处：《江苏医药》2012年第3期278-280,共3页Jiangsu Medical Journal

基　　金：江苏省自然基金资助(BK2010121)

摘　　要：目的评价依帕司他与甲钴胺联合应用治疗糖尿病周围神经病变的疗效与安全性。方法检索CNKI数据库,收集以依帕司他与甲钴胺联合应用为干预措施治疗糖尿病周围神经病变的随机对照研究。对纳入的研究文献进行方法学质量评价,提取有效数据进行Meta分析。结果共纳入6个随机对照研究,共纳入糖尿病周围神经病变患者496例。试验组为基础治疗加依帕司他与甲钴胺联合应用,对照组为基础治疗加B族维生素。Meta分析结果显示,试验组在改善糖尿病周围神经病变患者的临床症状的有效率方面优于对照组(P<0.01,OR=3.58,95%CI=2.26-5.66)。结论依帕司他与甲钴胺联合应用对糖尿病周围神经病变患者的临床症状有改善作用。Objective To evaluate the efficacy and safety of epalrestat combined with methylcobalamin in treating diabetic peripheral neuropathy.Methods The electronic databases CNKI was searched to collect the randomized controlled trials of epalrestat combined with methylcobalamin for the treatment of diabetic peripheral neuropathy.The methodological quality of the trials was evaluated and the valid data for Meta-analysis were extracted.Results Six randomized controlled trials（496 cases） were included.In addition to conventional basic treatments,test group was treated with additional epalrestat combined with methylcobalamin,while control group was treated with additional B vitamins.Meta analysis showed that the patients in test group was better than those in control group in the improvement of clinical symptoms（P0.01,OR=3.58,95%CI=2.26-5.66）.ConclusionThe Meta analysis on this group shows that epalrestat combined with methylcobalamin can improve the clinical symptoms in the patients with diabetic peripheral neuropathy.

关 键 词：依帕司他 甲钴胺 糖尿病周围神经病变 

分 类 号：R587[医药卫生—内分泌]