生脉保元汤治疗扩张型心肌病的临床研究  

Sheng Mai Bao Yuan Soup(SMBY) in treatment of dilated cardiomyopathy

作　　者：张焕鑫[1] 张宏考[1] 肖俊会[1] 高宇勤[1] 赵继先[1] 

机构地区：[1]湖北医药学院附属人民医院心内科,湖北十堰442000

出　　处：《临床心血管病杂志》2012年第2期101-103,共3页Journal of Clinical Cardiology

摘　　要：目的:观察生脉保元汤对扩张型心肌病(DCM)患者临床表现、心功能等方面的影响,并分析其可能机制。方法:将40例DCM患者随机分为对照组(20例)与治疗组(20例),2组均用西药常规药物治疗,治疗组同时给予生脉保元汤口服。观察2组患者症状、体征、心功能及心脏超声的变化,治疗6个月后参照《中药新药临床研究指导原则》评价疗效。结果:治疗组在临床症状发生率、心功能分级、左室射血分数及有效率方面明显优于对照组(均P<0.05)。结论:生脉保元汤能显著改善DCM患者的临床表现、心功能,与西药联合应用能取得更好的治疗效果,同时能明显提高DCM患者的临床疗效及生存质量。Objective：To observe the effect of chinese traditional medicine——Sheng Mai Bao Yuan Soup（SMBY） on the clinical manifestations,cardiac function and other aspects in patients with dilated cardiomyopathy（DCM）,and explore its possible mechanism. Method：Forty patients with DCM were randomly divided into 2 groups： the treatment group（n=20） and the control group（n=20）.The patients in both groups were treated with routine western medicine,while the patients in treatment group were traeted with SMBY in addition.The changes of symptoms,signs,cardiac function and cardiac ultrasound were observed before and after treatment in both groups,and the treatment effects were evaluated according to ＂Guiding principles for the clinical study of new Chinese Medicines＂ after six months. Result：The incidence of clinical symptoms,cardiac functional capacity classification,left ventricular ejection fraction and effective rate in treatment group were obviously better than those of control group（P0.05）. Conclusion：SMBY can obviously improve the clinical manifestations and cardiac function in patients with DCM,which will be more effective if it is used with western medicine together,and can obviously improve the clinical efficacy and quality of life.

关 键 词：扩张型心肌病 生脉保元汤 心功能不全 

分 类 号：R542.2[医药卫生—心血管疾病]