MicroRNA及其在糖尿病视网膜病变中的研究进展  

MicroRNA and its effect on diabetic retinopathy

作　　者：张俊[1] 周琦[1] 吕红彬[1] 

机构地区：[1]泸州医学院附属医院眼科,四川省泸州市646000

出　　处：《眼科新进展》2012年第2期192-195,共4页Recent Advances in Ophthalmology

基　　金：四川省教育厅基金资助(编号:08ZA092)~~

摘　　要：MicroRNA(miRNA)是近年来发现的一类长度21～25个核苷酸的单链小分子RNA,它们参与调节细胞的生长发育、分化、增殖和凋亡等。miRNA主要通过与靶基因转录的mRNA部分或者完全互补配对结合,在转录后水平对靶基因的表达进行调节。最近,越来越多证据表明,miRNA在调节糖尿病及其并发症中发挥重要的作用,其通过密切相关的多种生物学途径对糖尿病视网膜病变进行调节。本文就miRNA的发现、生物合成和作用机制、功能及其在糖尿病视网膜病变中的调节作用进行综述。MicroRNA（miRNA） is a recently discovered class size of about 21 to 25 nucleotides single-stranded small molecule RNA,which involves in regulating cell growth,differentiation,proliferation and apoptosis regulation.They mainly target gene transcription by the mRNA with partially or completely complementary pair combination of post-transcriptional level to regulate the expression of target genes.Recently,more and more evidences have showed that miRNA plays an important role in the regulation of diabetes and its complications,through a variety of closely related biological pathways regulated in diabetic retinopathy.In this paper,the origin,structure,function of miRNA and its regulation in the diabetic retinopathy are reviewed.

关 键 词：MICRORNA 基因调控 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌]