基于切伦科夫效应的裸鼠甲状腺^131I多模态显像  

Multimodality imaging of ^131I uptake in nude mice thyroid based on Cerenkov radiation

作　　者：胡振华[1] 梁继民[1] 屈晓超[1] 杨卫东[2] 马晓伟[2] 汪静[2] 田捷[3] 

机构地区：[1]西安电子科技大学、生命科学技术学院,710071 [2]第四军医大学西京医院核医学科 [3]中国科学院自动化研究所

出　　处：《中华核医学与分子影像杂志》2012年第1期29-31,共3页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家重点基础研究发展计划（973计划）（2011CB707702）;国家自然科学基金（81000632,30900334,81101083,81101084）

摘　　要：目的 采用切伦科夫发光断层成像（CLT）和γ显像进行裸鼠甲状腺摄取^131I的多模态成像，探索CLT与γ显像之间的相关性。方法先对4只裸鼠[体质量（21±3）g]尾静脉注射1．67×10^7Bq^131I，在注药后0．5、3、12及24h均分别行CLT和γ显像。采用基于漫射方程（DE）的切伦科夫光源重建方法重建裸鼠体内^131I的生物分布及在不同采集时间点甲状腺摄取^131I的切伦科夫光的功率。对采集的γ显像图像勾画ROI，获得γ计数的平均值，对CLT^131I的切伦科夫光的功率和γ显像获取的γ计数行直线相关分析。结果甲状腺摄取^131I的切伦科夫光的功率在0．5、3、12和24h分别为7．80×10^13、1．62×10^12、2．20×10^-12和2．68X10^12W。甲状腺摄取^131I的切伦科夫光的功率随放射性药物注射时间的延长而逐渐增加。γ显像结果表明^131I在裸鼠腹部的摄取逐渐降低，而在甲状腺的摄取越来越高，CLT与γ显像结果具有较好的相关性（r^2=0．7620，P〈0．05）。结论CLT具有临床甲状腺成像、甲状腺疾病诊断和疗效判断的潜力。Objective To perform the multimodality ^131I thyroid imaging using Cerenkov lumines- cence tomography （CLT） and gamma imaging, and to compare the results of CLT and gamma imaging. Meth- ods The nude mice （ n = 4, mass ： （21±3） g） were injected with 1.67 ×107 Bq ^131 I. CLT and gamma im- aging were acquired at 0. 5, 3, 12 and 24 h after the injection. Three-dimensional biodistribution of ^131I uptake in thyroid was reconstructed using Cerenkov source reconstruction method based on the diffusion equa- tion （DE）, and the reconstructed power of ^131I in different acquisition time points was obtained. Additional- ly, the ROIs were drawn over the gamma images of the mouse neck, and the counts were read. The correla-tion between the reconstructed power of CLT and gamma ray counts of gamma imaging was analyzed. Re- suits The power of ^131I uptake in thyroid at 0. 5, 3, 12 and 24 h were 7. 80 ×10^-13, 1.62×10^-12,2.20× 10-12 and 2. 68×10^-12 W, respectively. CLT results showed that reconstructed power increased with the increasing of acquisition time. Gamma imaging results indicated that ^131I uptake decreased in abdomen and in- creased in thyroid with the collection time. The results of CLT were consistent with that of gamma imaging （r^2 = 0.7620, P 〈 0. 05 ）. Conclusion CLT has the potential to identify and monitor functioning thyroid tissue at before and （or） after^131I treatment.

关 键 词：切伦科夫光学成像 碘放射性同位素 甲状腺 小鼠 裸 放射性核素显像 

分 类 号：R817.4[医药卫生—影像医学与核医学]