肾康注射液联合低分子量肝素钠注射液对原发性肾病综合征高凝状态的影响  

Effect of Shenkang injection combined with low molecular weight heparin sodium injection on a hypercoagulable state of the primary nephrotic syndrome

作　　者：牛凯[1] 冯珍[1] 刘冰[1] 史亚男[1] 董春霞[1] 

机构地区：[1]河北省人民医院肾内科,河北石家庄050051

出　　处：《河北中医》2011年第12期1904-1905,1920,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察肾康注射液联合低分子量肝素钠注射液对原发性肾病综合征(PNS)高凝状态的影响。方法将88例PNS患者随机分为4组,均予常规降压、调脂治疗,并口服甲基强的松龙。双嘧达莫片组21例,加用双嘧达莫片治疗;肾康注射液组22例,加用肾康注射液治疗;低分子量肝素钠注射液组22例,加用低分子量肝素钠注射液治疗;联合治疗组23例,加用肾康注射液联合低分子量肝素钠注射液治疗。4组疗程均为2周。观察治疗前后24 h尿蛋白定量、血浆白蛋白、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)变化。结果肾康注射液组、低分子量肝素钠注射液组治疗后24 h尿蛋白定量、FIB均较双嘧达莫片组下降(P<0.05),血浆白蛋白、PT、APTT均较对照组升高(P<0.05)。肾康注射液组24 h尿蛋白定量较低分子量肝素钠注射液组下降明显(P<0.05),血浆白蛋白升高明显(P<0.05)。联合治疗组治疗后24 h尿蛋白定量、FIB均较其余3组显著下降(P<0.05),血浆白蛋白、PT、APTT均较其余3组显著升高(P<0.05)。结论肾康注射液联合低分子量肝素钠注射液治疗PNS高凝状态有明显疗效,且未出现明显的不良反应。Objective To investigate the effect of Shenkang injection combined with low molecular weight heparin sodium injection on a hypercoagulable state of the primary nephrotic syndrome.Methods 88 patients with primary nephrotic syndrome（PNS） were randomly divided into four groups,Dipyridamole tablets group,Shenkang injection group,low molecular weight heparin sodium injection group and combination therapy group.Patients in four groups were treated by conventional blood pressure,lipid lowering therapy,and oral methylprednisolone.Dipyridamole tablets group（n=21） received Dipyridamole tablets.Shenkang injection group（n=22） and low molecular weight heparin sodium injection group（n=22） separately received Shenkang injection and low molecular weight heparin sodium injection.Combination therapy group（n=23） received Shenkang injection combined with low molecular weight heparin sodium injection.The course was four weeks in four groups.The changes of 24 h urinary protein excretion,serum albumin,prothrombin time（PT）,activated partial thromboplastin enzyme time（APTT） and fibrinogen（FIB） were measured before and after treatment.Results 24 h urinary protein excretion and FIB in Shenkang injection group and low molecular weight heparin sodium injection group were decreased as compared with those in Dipyridamole tablets group（P〈0.05）.Plasma albumin,PT and APTT in Shenkang injection group and low molecular weight heparin sodium injection group were increased as compared with those in control group（P〈0.05）.24 h urine protein excretion in Shenkang injection group was decreased as compared with that in low molecular weight heparin sodium injection group（P〈0.05）,plasma albumin was increased（P〈0.05）.24 h urinary protein excretion and FIB in combination therapy group were significantly decreased as compared with those in other three treatment groups（P〈0.05）.Plasma albumin,PT and APTT were obviously increased in comparison with those in other three groups（P〈0.05）.Conclusion S

关 键 词：肾病综合征 并发症 血液凝固障碍 纤维蛋白原 血蛋白质类 血栓形成 肝素 低分子量 

分 类 号：R341[医药卫生—基础医学] R543.025