诺氟沙星在奥尼罗非鱼体内的药代动力学及残留研究  

Pharmacokinetics and Residues of Norfloxacin in Hybrid Tilapia

作　　者：廖碧钗[1,2] 

机构地区：[1]福建省淡水水产研究所,福建福州350002 [2]福建省水产技术推广总站,福建福州350003

出　　处：《福建农业学报》2011年第6期930-934,共5页Fujian Journal of Agricultural Sciences

基　　金：福建省海洋与渔业厅重点项目(2009 1-15);国家现代农业产业技术体系建设项目(CARS-49);福建省种业创新与产业化工程项目(2011FJZY);公益性行业(农业)科研专项(200803013)

摘　　要：在水温(25±2)℃条件下,以20mg.kg-1鱼体重的剂量给奥尼罗非鱼单次口灌诺氟沙星,高效液相色谱法测定血浆和肌肉组织中的药物浓度,研究诺氟沙星在奥尼罗非鱼体内的代谢及消除规律。结果显示:血药时间数据符合一级吸收二室开放模型,半衰期(T1/2 Ka、T1/2α、T1/2β)分别为1.30、1.97、26.36h,最大血药浓度为0.546μg.mL-1,达峰时间为2.715h,药时曲线下面积(AUC)为14.491μg.h.mL-1。选取肌肉组织作为残留检测的靶组织,以10μg.kg-1为最高残留限量,在本试验条件下,建议休药期不低于55d。In order to study the metabolism and elimination of norfloxacin（NFX） in hybrid tilapias（Oreochromis aureus×O.niloticus）,single oral administration at dose of 20 mg·kg-1 had been investigated in healthy tilapia at（25±2）℃.The result demonstrated： Plasma concentration-time datas of NFX were best fitted using a two-compartmental open model.Absorption,distribution and elimination half-life were 1.30,1.97 and 26.36 hours,respectively.The maximal plasma concentration was 0.546 μg·mL-1,peaking at 2.715 hour.Area under the plasma drug concentration-time curve was 14.491 μg·h·mL-1.As an edible tissue,muscle was selected as target tissue in this experiment.The maximum residue limit（MRL） is 10 μg·kg-1 in muscle,the withdrawal time should not be less than 55 days under this experiment condition.

关 键 词：诺氟沙星 奥尼罗非鱼 药代动力学 残留 

分 类 号：S859.84[农业科学—临床兽医学]