微波诱发工作人员外周血淋巴细胞亚群变化情况调查  

Effects of Microwave Radiation on T Lymphocytes of Workers

作　　者：尹金玲[1] 满其航[1] 崔玉芳[2] 杜丽[2] 

机构地区：[1]航天中心医院职业病科,北京100049 [2]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《辐射防护通讯》2011年第5期14-17,共4页Radiation Protection Bulletin

基　　金：国家自然科学基金(39000386);毫米波国家重点实验室开放课题(K200909);军队医药卫生"十一五"基金(09MA026)

摘　　要：对某研究所微波接触人员(接触组)和非微波作业人员(对照组)进行调查,调查指标为外周血白细胞数和淋巴细胞百分率,以及T淋巴细胞亚群CD3+、CD4+、CD8+比例和CD4+/CD8+比值,探索长期低剂量高功率微波辐射对工作人员免疫功能的影响。结果表明:与对照组相比,接触组白细胞数和淋巴细胞百分比均降低,但差异不显著;接触组CD3+、CD4+、CD8+比例均升高,CD4+/CD8+比值降低,差异显著;接触组≤10 a组的T细胞亚群的变化差异不显著,接触组>10 a组CD3+、CD4+、CD8+比例及CD4+/CD8+比值均升高,且CD3+比例升高差异显著;接触组和对照组组内工龄≤10 a和〉10 a间T淋巴细胞亚群的差异不显著。结果提示,低剂量高功率微波辐射能明显导致人体免疫功能紊乱,但未表现出累积效应。客观有效的职业防护应当引起关注。To investigate the effects of long-term, low-dose and high-power microwave radiation on immuno-logic function of workers. The changes of peripheral blood leukocytes, lymphocyte percentage, and CD3＋ , CD4＋ , CD8＋ T cells and ratios of CD4＋/CD8＋ were determined in 38 microwave radiation-exposed workers （exposed group） and 39 non-microwave radiation-exposed workers （control group）. Compared with the control group, peripheral blood leukocytes and lymphocyte percentage were decreased in the exposed group, but the difference was not significant. CD3＋, CD4＋ , CD8＋ cells were increased significantly and ratio of CD4＋/ CD8＋ was diminished significantly in the exposed group. In the exposed group, T cell subsets in ≤ 10 years service length group was not significant as compared with the control group. But CD3＋, CD4＋ , CD8＋ cells and ratio of CD4＋/CD8＋ were increased in 〉 10 years service length group of the exposed group, and CD3＋ cells were increased significantly. Inaddition, 2 service length groups within the exposed group and control group, CD3＋, CD4＋ , CD8＋ T ceils and ratio of CD4＋/CD8＋ were not significant. The Long-term, low-dosage and high-power microwave radiation can cause significant immune dysfunction to the exposed workers, but without cumulative effects. Effective occupational protection should be adopted.

关 键 词：微波 淋巴细胞 T淋巴细胞亚群 

分 类 号：R131[医药卫生—劳动卫生]