中药制剂直肠外用防治宫颈癌放疗所致放射性直肠炎的临床研究  

The Prevention and Treatment of the Radiation-induced Proctitis with Herbal Medicine Administered to Rectum in Patients with Cervical Carcinoma

作　　者：马建萍[1] 赵仁[1] 何剑莉[1] 楚国庆[1] 刘长虎[1] 杨治花[1] 折虹[1] 丁喆[1] 海平[1] 

机构地区：[1]宁夏医科大学总医院放疗科,银川750004

出　　处：《宁夏医科大学学报》2011年第12期1147-1149,共3页Journal of Ningxia Medical University

基　　金：2009年银川市科技攻关项目

摘　　要：目的探讨中药制剂直肠外用防治宫颈癌放疗引起的放射性直肠炎的临床价值。方法将90例Ⅰ～Ⅲ期宫颈癌患者随机分为研究组和对照组,每组45例,两组放疗方法相同,研究组在放疗开始给予中药制剂直肠外用至放疗结束,对照组直肠局部不用药物干预。放疗期间和放疗后观察放射性直肠炎发生情况及严重程度。结果研究组和对照组急性放射性直肠炎的发生率分别为37.8%(17/45)、64.4%(29/45),慢性放射性直肠炎的发生率分别为2%(1/45)、11%(5/45),(P均<0.05);两组Ⅱ级以上急性放射性直肠炎发生率分别为15.6%(7/45)、44.4%(20/45),(P<0.05);两组患者急性放射性直肠炎持续时间分别为(0.9±1.3)周和(5.2±8.1)周(P<0.05)。对照组和研究组放疗开始后前3周内急性放射性直肠炎发生率分别为58.6%(12/29)和29.4%(5/17)(P>0.05)。结论采用中药制剂直肠外用可降低宫颈癌放疗所致的放射性直肠炎的发生率,并能缓解其症状,从而减轻患者的痛苦并提高患者生活质量。Objective To explore the prevention and treatment with herbal medicine for acute rectal injury induced by radiotherapy in patients with cervical carcinoma.Methods 90 cases with grade Ⅰ～Ⅲ cervical carcinoma treated with radiotherapy were divided into two group randomly.45 cases were administered with herbal medicine to rectum during radiotherapy.The other 45 cases did not administered with medicine to rectum.The acute and late rectal injury were observed and recorded.Results The acute and late radiation-induced proctitis incidence in study group was significantly lower than that in control group.The proctitis was significantly more serious in the control group and the continuous time of proctitis was significantly shorter in study group.Conclusion It is possible to prevent and treat radiation-induced proctitis when patients with cervical carcinoma take herbal medicine during radiotherapy.

关 键 词：宫颈癌 放射治疗 放射性直肠炎 中药 

分 类 号：R273[医药卫生—中西医结合]