不同程度高胆红素血症对新生儿排尿方式影响的初步研究  被引量:4

Voiding pattern of term newborns with hyperbilirubinemia

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作  者:文建国[1] 李燕[1] 张茜[2] 王亚仑[1] 陈燕[1] 杨黎[1] 娄安锋[1] 张艳[1] 任川[1] 李一冬[1] 

机构地区:[1]河南省高等学校临床医学重点学科开放实验室、郑州大学第一附属医院泌尿外科、小儿尿动力学中心,郑州450052 [2]河南省高等学校临床医学重点学科开放实验室、郑州大学第一附属医院NICU,郑州450052

出  处:《中华小儿外科杂志》2012年第2期105-108,共4页Chinese Journal of Pediatric Surgery

摘  要:目的 探讨不同程度高胆红素血症对新生儿排尿方式的影响.方法 选取出生后4~15d确诊为高胆红素血症新生儿33例,根据不同血清总胆红素(Tbil)水平,分为轻中度高胆组(mild to moderate hyperbilirubinemia,MHB)和重度高胆组(severe hyperbilirubinemia,SHB).其中MHB组18例,胎龄(38.6±2.1)周,体重(3.1±0.3)kg; SHB组15例,胎龄(38.9±1.8)周,体重(3.4±0.4) kg.连续4h观察新生儿排尿,记录排尿次数、每次尿量、残余尿量、排尿时觉醒状态.同时选取胆红素水平正常新生儿19例为对照组.比较各组参数的差异.结果 SHB组排尿次数和残余尿量分别为(3.3±1.1)次和(1.8±0.5) ml,显著高于正常组[(2.7±0.8)次和(1.3±0.8)ml]和MHB组[(2.7±0.8)次,(1.4±(0.7) ml],(P<0.05);平均每次排尿量(23.1±8.3)ml明显低于正常组(27.8±7.3) ml和MHB组(26.9±5.6) ml,(P<0.05).排尿时清醒状态百分比在三组之间无统计学差异(P>0.05).结论 SHB新生儿排尿方式明显改变.排尿方式的改变是否与重度高胆红素血症影响新生儿排尿中枢有关有待进一步研究.Objective To explore the effect of different degree of hyperbilirubinemia on the voiding pattern of newborn.Methods Four-hour voiding observations were performed on 52 newborns with the gestational ages ranged from 37 to 42 weeks.Of whom,18 had mild to moderate hyperbilirubinemia (MHB) [blood total bilirubin level (Tbil) ranged from 221 μtmol/l to 342μmol/l] ; 15 had severe hyperbilirubinemia (SHB) (Tbil 〉342μmol/l).Nineteen babies had normal bilirubin level (NB) (Tbil 〈221 μmol/l).The voiding frequency (VF),voiding volume (VV),post-void residual volume (PRV),and percentage of awake voiding (AVP) of every infant from 8AM to 12AM were recorded.A total of 328 voids were observed in this study.Results The VF and PVR [ (3.3 ± 1.1 ) times,( 1.8 ± 0.5) ml] of SHB is higher than NB [(2.7 ± 0.8) times,(1.3 ± 0.8) ml] and MHB [(2.7 ± 0.8) times,(1.4 ±0.7) ml] (P〈0.05).The VV of SHB(23.1 ± 8.3) ml is lower than NB(27.8 ± 7.3) ml and MHB (26.9 ± 5.6) ml(P〈0.05).There is no difference of AVP among 3 groups.Conclusions There is a significant change of voiding pattern in newborn with severe hyperbilirubinemia,suggesting that severe hyperbilirubinemia has an effect on the nerve micturition center.

关 键 词:高胆红素血症 新生儿 排尿 

分 类 号:R722.1[医药卫生—儿科]

 

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