口服缓控释制剂在心血管药物研究中的应用  

Application of Oral controlled release system in the research of cardiovascular disease

作　　者：凌丽[1] 

机构地区：[1]广州军区总医院药剂科,广州510010

出　　处：《中山大学研究生学刊（自然科学与医学版）》2011年第3期1-7,共7页Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)

摘　　要：口服缓控释制剂可以缓慢、持久地传递药物,减少用药频率(作用时间长,使用方便,增加病人依从性),避免或减少血药浓度"峰谷"现象(血药浓度平稳,减低毒副作用,改善疗效),深受临床和病人的欢迎。为了预防心血管疾病的发作,研制可以平稳给药和择时给药的缓控释制剂已经成为必然趋势。本文通过查询文献和资料对各种应用于心血管药物的缓控释如片剂(骨架片、渗透泵片、脉冲片、包衣片)、微丸和其他新剂型等作一概述。Oral controlled release system can sustain or prolong the frequency of drug release to prevent the ＂Burst-release＂ of the medicine concentration, and it is extensively used in clinical. In order to prevent the occurrence of cardiovascular disease, the development of a smooth delivery and timing of administration of controlled release drugs become an inevitable trend. In this paper, we made a conlusivaly review on a variety of cardiovascular controlled release formulations such as tablets （matrix, osmotic pump, pulse, Coating）, pellets, and other new formulations.

关 键 词：缓控释制剂 心血管药物 应用 

分 类 号：TQ463.54[化学工程—制药化工]