血清胰岛素样生长因子-1与早产儿体格生长的关系  

The relationship between serum level of insulin-like growth factor-1 and physical development of premature infants

作　　者：翁立坚[1] 房晓祎[1] 林霓阳[1] 

机构地区：[1]广东省汕头大学医学院第一附属医院儿科,515041

出　　处：《中国临床研究》2012年第2期118-119,共2页Chinese Journal of Clinical Research

摘　　要：目的探讨早产儿血清胰岛素样生长因子-1(IGF-1)水平变化与早产儿体格生长的关系。方法收集2006年2月至2007年2月在我院新生儿中心住院的30例无严重疾病早产儿的临床资料,以放射免疫分析法检测其在不同日龄(生后第1、7、12天)时血清IGF-1水平,分析不同日龄早产儿体重、体质指数(BMI)的变化及与IGF-1水平变化之间的关系。结果生后第1、7、12天早产儿体重分别为(1.89±0.35)、(1.84±0.25)和(2.20±0.26)kg(P<0.01),BMI分别为(10.03±1.04)、(9.35±0.80)和(11.06±0.82)kg/m2(P<0.01),不同检测日两两比较差异亦均有统计学意义(P均<0.01);生后第1、7、12天早产儿血清IGF-1水平分别为(37.76±7.07)、(34.33±8.97)和(50.19±8.38)ng/ml(P<0.01),不同检测日两两比较差异亦均有统计学意义(P均<0.01);血清IGF-1水平、体重及BMI均存在第7天下降、第12天上升(超过第1天)的趋势,且血清IGF-1水平与生后体重及BMI变化呈正相关(P均<0.01)。结论早产儿血清IGF-1水平变化与其体重、BMI存在正相关关系。推测IGF-1对早产儿的生长发育有调节作用。Objective To explore the relationship between serum levels of insulin-like growth factor-1 （ IGF-1 ） and the physical development in premature infants. Methods Clinical data including body weight, body mass index （BMI） and IGF-1 from 30 premature infants without severe diseases hospitalized in our center from February 2006 to February 2007 were recruited in this study to investigate the relationship between serum levels of IGF-1 and physical development of premature in- fants. The serum levels of IGF-1 at 1,7 and 12 days after birth were respectively measured by radioimmunoassay,and the relationships between changes of body weight, BMI and the levels of serum IGF-1 at different day-age in premature infants was analyzed. Results At 1,7 and 12 days after birth,the weights were （1.89 ±0.35） ,（1.84 ±0.25） and（2.20 ±0.26）kg,respectively （P 〈0. 01 ） ;the BMI were （ 10.03 ± 1.04）, （9.35 ±0.80） and （ 11.06 ±0.82 ） kg/m^2 ,respectively （P 〈0.01 ） ; the levels of serum IGF-1 were（37.76 ± 7.07 ）, （ 34.33± 8.97 ） and （ 50.19 ± 8.38 ） ng/ml, respectively （ P 〈 0. 01 ）. The aforementioned indexes were compared with each other in both of them at different time, there were also significant differences, respectively （ all P 〈 0. 01 ）. All of them presented a deseending tendency at 7th after birth and a re-ascending tendency over the first day at 12th after birth,and the levels of serum IGF-1 were positively correlated with body weight and BMI （ all P 〈 0. 01 ）, namely the levels of serum IGF-1 might be in keeping with the physical development of premature infants. Conclusions There were positive correlations between the serum IGF-1 level and body weight, BMI. IGF-1 might plays a regulating role on the physical development of premature infants.

关 键 词：胰岛素样生长因子-1 体格发育 早产 新生儿 

分 类 号：R722[医药卫生—儿科]