家蚕雌蛾粉对阴虚雌性小鼠作用的研究  

Pharmacological effect of the female silkworm moth powder on yin-deficiency model female rat

作　　者：李有贵[1] 时连根[1] 

机构地区：[1]浙江大学动物科学学院,杭州310029

出　　处：《中药药理与临床》2011年第6期55-58,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：浙江省中医药科技重点项目(2010ZZ006)

摘　　要：目的:研究家蚕雌蛾粉对阴虚雌性小鼠的药理作用。方法:灌胃甲状腺素联合利血平制作阴虚模型,灌胃给予家蚕雌蛾粉,YLS-1A多功能小鼠自主活动记录仪测定小鼠自主活动次数,腹腔注射0.6%冰醋酸观察小鼠扭体次数,游泳试验观察小鼠游泳存活时间,称量体重和脾脏、子宫卵巢的湿重计算器官系数。结果:家蚕雌蛾粉可显著减少阴虚雌性小鼠的自主活动次数,低剂量(3 g/kg)组、中剂量(6 g/kg)组和高剂量(12 g/kg)组的降低幅度均达极显著水平(P<0.01);家蚕雌蛾粉能显著减少阴虚雌性小鼠由冰醋酸引起的扭体次数,中剂量(6 g/kg)组的减少幅度达到显著水平(P<0.05),高剂量(12 g/kg)组的减少幅度达到极显著水平(P<0.01);家蚕雌蛾粉可以明显延长阴虚雌性小鼠的游泳存活时间,中剂量(6 g/kg)组和高剂量(12 g/kg)组的延长幅度均达极显著水平(P<0.01),低剂量(3 g/kg)组的延长幅度达显著水平(P<0.05);家蚕雌蛾粉可明显提高阴虚雌性小鼠体重,低剂量(3g/kg)组、中剂量(6 g/kg)组和高剂量(12 g/kg)组的提高幅度均达到极显著水平(P<0.01);家蚕雌蛾粉能显著改善阴虚雌性小鼠脾脏和子宫卵巢严重萎缩状况,低剂量(3 g/kg)组、中剂量(6 g/kg)组、高剂量(12 g/kg)组的脾脏系数和子宫卵巢系数的提高幅度均达极显著水平(P<0.01)。结论 :家蚕雌蛾粉对阴虚雌性小鼠具有镇静、镇痛、增强耐力、促进生长和生殖器官、免疫器官发育的作用,表现出明显的类雌激素样生物学活性。Objective ：This paper was to study the pharmacological effect of the female silkworm moth powder on yin-deficiency model female rat.Methods：Using thyroxine and reserpine to generate a yin-deficiency female rat model by gastric perfusion.The model rats were divided randomly into different-dosage groups of female silkworm moth powder and model contrast group.The independent activity numbers were noted by YLS-1A rat independent activity noting apparatus.Writhing times and surviving times were observed by injecting 0.6% acetic acid in abdomen and swimming test,respectively.The weight of mouse body,spleen,uterus and ovaries and their corresponding coefficient were evaluated.Results：Female silkworm moth powder could significantly reduce the independent activity numbers of yin-deficiency female rats.The reduction of independent activity numbers in low dose（3 g/g）,middle dose（6 g/g） and high dose（12 g/g） group showed extremely significant difference（P0.01） compared to normal group.Female silkworm moth powder could significantly reduce the writhing times of yin-deficiency female rats by the acetic acid.The reduction of writhing times in middle dose group（6 g/g） showed significant difference（P0.05） compared to normal group,while in high dose group（12 g/g） showed extremely significant（P0.01）.Female silkworm moth powder could significantly extend survival time of yin-deficiency female rats by swimming.The extension of survival times in low dose group（3 g/kg） showed significant difference（P0.05） compared to normal group,while in middle dose（6 g/g） and high dose（12 g/g） group showed extremely significant（P0.01）.Female silkworm moth powder could significantly increase body weight of yin-deficiency female rats.The increase of body weight in low dose（3 g/g）,middle dose（6 g/g） and high dose（12 g/g） group showed extremely significant difference（P0.01） compared to normal group.Female silkworm moth powder could significantly improve the severe atrophy of organ

关 键 词：家蚕雌蛾粉 阴虚模型 雌性小鼠 药理作用 

分 类 号：R285[医药卫生—中药学]