两面针根和茎抗炎镇痛不同部位活性比较研究  

Studies on the anti-inflammatory and analgesic activities of different polarities from the roots and stems of Zanthoxylum nitidum DC.

作　　者：冯洁[1] 周劲帆[1] 覃富景[1] 梁春宏[1] 赖茂祥[2] 张海英[1] 

机构地区：[1]广西医科大学药学院,南宁530021 [2]广西中医药研究院,南宁530022

出　　处：《中药药理与临床》2011年第6期60-63,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：广西自然科学基金项目(2010GXNSFA013187);广西医科大学博士启动资金资助;广西中医药管理局中医药科技专项课题(GZKZ1141)

摘　　要：目的:研究两面针根和茎的不同部位抗炎、镇痛药理活性,为评价两面针茎能否成为抗炎镇痛的药用植物资源提供科学依据。方法:采用扭体法及热板法实验考察小鼠镇痛作用,应用小鼠耳廓肿胀、脚肿胀及棉球肉芽肿胀等实验综合评价两面针根及茎不同极性部位的抗炎活性。结果:除茎水层低剂量组的抗炎活性与模型组比较无显著性差异外,其余各部位的高、中、低剂量组(1 g/kg,0.5 g/kg,0.25 g/kg)与模型组比较,均有显著的抗炎和镇痛作用(P<0.05,P<0.01),根的正丁醇部位活性最强。结论:两面针根和茎均有抗炎镇痛活性,根的活性比茎强。Objective：To study the anti-inflammatory and analgesic activities of different polarities from the roots and stems of Zanthoxylum nitidum,to provide the scientific basis and reference for evaluating the stems of Zanthoxylum nitidum whether become the resources of medicinal plant of anti-inflammatory and analgesic activities.Methods：Acetic acid writhing method and hot-platemethod were used to study the analgesic activities.Auricle edema induced by dimethylbenzene,cotton pellet granuloma of the mice and edema in feet induced by carrageen for anti-inflammatory experiments.Result：Compared with model control group,anti-inflammatory of the stem water-extract had no significant difference（P 0.05）,the high,medium and low dose groups（1 g/kg,0.5 g/kg,0.25 g/kg） of other polarities showed obvious pharmacological effects（P 0.05,P 0.01）.N-Butanol extract from the roots showed the most intensive activity.Conclusion：The extract from the roots and stems can show anti-inflammatory and analgesic activities,whereas the activities of the roots were better than the stems.

关 键 词：两面针 抗炎 镇痛 

分 类 号：R285[医药卫生—中药学]