抗病毒片抗炎作用的实验研究  

Experimental Studies on Anti-inflammatory Effects of Anti-virus Tablets

作　　者：乔敏[1] 甘雨[1] 张宏[1] 邹德俊[2] 李国信[1] 

机构地区：[1]辽宁省中医药研究院,沈阳110034 [2]辽宁中医药大学,沈阳110032

出　　处：《实验动物科学》2011年第6期10-12,共3页Laboratory Animal Science

基　　金：国家科技部"十一五"重大新药创制项目(No.2009ZX09103-330)

摘　　要：目的研究抗病毒片的抗炎作用。方法采用小鼠腹腔毛细血管通透性法及对琼脂所致大鼠肉芽肿和对大鼠佐剂关节炎的影响进行实验。检测大鼠足趾肿胀、胸腺指数,评价其抗炎作用。结果抗病毒片能降低小鼠腹腔毛细血管通透性;对琼脂引起的大鼠肉芽肿有明显的抑制作用;对弗氏完全佐剂所致大鼠原发性肿胀有明显的抑制作用,胸腺指数升高,脾指数下降,白细胞介素1水平升高。结论抗病毒片具有抗炎的药理作用。Objective To observe theAnti-inflammatory effects of Anti-virus tablets.Method Experiment of rat agar-induced granuloma,the abdominal capillary permeability of mice.After AA rat models were established,the apricot kernel＇s antiarthritic effect on the changes of foot swelling、spleen indes、thymus index、tumor necrosis factor（TNF） and interleukin 1.Result Anti-virus tablets can reduce the abdominal capillary permeability;on agar granuloma caused significantly inhibited in rats;of Freund＇s complete adjuvant induced significantly inhibited primary swelling,the thymus index increased spleen index decreased levels of interleukin 1.Conclusion Anti-virus tablets have anti-inflammatory pharmacological effects.

关 键 词：抗病毒片 抗炎 药效学 

分 类 号：Q95-33[生物学—动物学]