Synthesis and Antibacterial Activity of Juglone Derivatives  

作　　者：Daniel Teoh Chuan Tan Hasnah Osman Suriyati Mohamad Azlina Harun Kamaruddin 

机构地区：[1]School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia [2]School of Biological Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia [3]School of Chemical Engineering, Universiti Sains Malaysia, Nibong Tebal 14300, Penang, Malaysia

出　　处：《Journal of Chemistry and Chemical Engineering》2012年第1期84-89,共6页化学与化工（英文版）

摘　　要：Nitro and halogen substituted derivatives of the juglone naphthoquinone were synthesized and assayed for their antibacterial activity. 8-Nitrojuglone was obtained as the exclusive product from the direct nitration of juglone with nickel （Ⅱ） nitrate and p-toluenesulphonic acid. In addition, a series of five 8-halojuglone derivatives were synthesized via a solvent-free Friedel-Crafts acylation reaction. One of the acylation reactions afforded an anthraquinone-type derivative as the minor product. The 8-nitrojuglone derivative displayed the most notable activity against S. aureus. However, all of the 8-halojuglone derivatives were found to be less active than juglone against the bacteria assayed.

关 键 词：NAPHTHOQUINONE NITRATION Friedel-Crafts acylation ANTHRAQUINONE antibacterial activity. 

分 类 号：TQ460.3[化学工程—制药化工] O627.8[理学—有机化学]