川崎病患儿外周血循环内皮细胞水平变化与冠状动脉损伤关系的探讨  

The relationship of peripheral circulating endothelial cell level and the coronary artery lesion in children with Kawasaki disease

作　　者：周雅娟[1] 于宪一[1] 孙璐[1] 

机构地区：[1]中国医科大学附属盛京医院小儿循环内科,沈阳110004

出　　处：《中国小儿急救医学》2012年第1期35-37,共3页Chinese Pediatric Emergency Medicine

基　　金：辽宁省教育厅科学研究项目（2008805）;沈阳市科学技术项目（F11-264-1-30）

摘　　要：目的通过观察川崎病患儿外周血循环内皮细胞（circulating endothelial cell，CEC）水平的变化与患儿冠状动脉损伤（coronary artery lesion，CAL）的关系，进一步探讨川崎病早期诊断的方法。方法研究对象为30例川崎病患儿，其中23例为完全型川崎病，7例为不完全型川崎病。根据超声心动图检查结果将川崎病组又分为CAL组9例和冠状动脉无损伤（non-coronary artery lesion，NCAL）组21例。对照组为10例健康体检儿童。采用双盲对照研究法，利用Hladovec法计数CEC。结果川崎病组患儿CEC为（1．09±0．60）×10^7／L，高于正常对照组[（0．38±0．14）×10^7／L]，差异有统计学意义（t=2．85，P〈0．01）。CAL组患儿CEC为（1．84±0．24）×10^7／L，高于NCAL组[（2．01±0．38）×10^7／L]，差异有统计学意义（t=2．24，P〈0．05）。完全型川崎病组患儿CEC数量为（1．16±0．63）×10^7／L，不完全型川崎病组患儿CEC数量为（0．83±0．45）×10^7／L，两组差异无统计学意义（t=1．86，P〉0．05）。结论川崎病急性期患儿CEC水平升高明显，急性期CAL组CEC水平高于NCAL组，CEC水平的检测有助于川崎病的早期诊断。Objective To investigate the relationship between the change of circulating endothelial cell （CEC） level and coronary artery lesion （CAL） of Kawasaki disease （ KD）, and to further explore the method for early diagnosis of KD. Methods Thirty KD children were recruited for study,including 23 children with complete type of KD and seven children with incomplete KD. According to the results of echocardiography, the KD group was divided into CAL group （9 cases） and non-coronary artery lesion （NCAL） group （21 cases）. Ten healthy children were enrolled as control group. Double-blind and controlled trial was conducted, and Hladovec method was applied for CEC counting. Results The CEC level was （1.09 ± 0.60） × 10^7/L in KD group,which was higher than that of control group [ （0. 38 ±0. 14） × 10^7/L] ,and the difference was statistically significant （ t = 2. 85, P 〈 0. 01 ）. The CEC level in the CAL group [ （ 1.84 ± 0. 24）× 10^7/L] was higher than that of the NCAL group[ （2. 01 ±0.38） × 10^7/L] ,and the difference was statistically significant （ t = 2. 24, P 〈 0. 05 ）. The CEC level was （ 1.16 ± 0. 63 ） x 107/L in the complete type of KD group and （0. 83 ± 0. 45 ） × 10^7/L in the incomplete KD group, which showed no significant difference between the two groups （t = 1.86, P 〉 0. 05 ）. Conclusion CEC level was elevated significantly in the acute phase of KD. The CEC level in CAL group was higher than that of NCAL group in acute phase. CEC level detection may be helpful for the early diagnosis of KD.

关 键 词：川崎病 循环内皮细胞 冠状动脉损伤 

分 类 号：R725.4[医药卫生—儿科]