2005-2008年脑膜脓毒金黄杆菌医院感染及qacE△1基因的监测  

Clinical characteristics of Chryseobacterium meningosepticuminfection and drug resistant gene of qacE △1 from 2005 to 2008

作　　者：时东彦[1] 张静[1] 李扬[1] 苏军华[1] 付杰[1] 

机构地区：[1]河北医科大学第二医院检验科,河北石家庄050000

出　　处：《中华医院感染学杂志》2012年第4期661-663,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解脑膜脓毒金黄杆菌临床感染特点和耐药现状。方法对2005-2008年从各类临床标本中分离到的脑膜脓毒金黄杆菌株统一用K-B法进行体外药敏试验,并对患者资料进行统计分析;应用PCR基因扩增技术检测耐消毒剂qacE△1。结果分离菌株最多的病区是ICU,占43.7%,其次为呼吸科,占22.9%;药敏试验结果表明,该菌对阿米卡星、庆大霉素和环丙沙星、左氧氟沙星、亚胺培南、美罗培南耐药率>80.0%,对磺胺甲噁唑/甲氧苄啶、头孢他啶、头孢吡肟耐药率>70.0%,对哌拉西林/他唑巴坦耐药率最低,为16.7%,其次为头孢哌酮/舒巴坦47.9%;消毒剂基因qacE△1阳性率为8.3%。结论脑膜脓毒金黄杆菌对多种抗菌药物具有较高的耐药性,临床抗感染治疗应以分离菌株的体外抗菌药物敏感性为依据。OBJECTIVE To study the clinical characteristics of Chryseobacterium meningosepticum infection and the current drug resistance.METHODS In vitro drug susceptibility testing was performed on C.meningosepticum isolated from clinical specimens with K-B method from 2005 to 2008,and the patients＇data were analyzed statistically.Meanwhile,the gene of qacE△1 was analyzed by polymerase chain reation（PCR）.RESULTS The isolates were the most common in ICU（43.7%）,followed by respiratory department（22.9%）;The resistance rates to gentimycin,amikacin,ciprofloxacin,levofloxacin,meropenem and imipenem were more than 80.0 %,and to sulfamethoxazole compound,ceftazidime and cefepime were more than 70.0%.The resistance rates to piperacillin/tazobactam and cefoperazone/sulbactam were only 16.7% and 47.9%,respectively.The positive rate of qacE△1 gene was 8.3%.CONCLUSION C.meningosepticum is highly resistant to most antibiotics.The treatment of C.meningosepticum infection should be based on the results of in vitro drug susceptibility testing.

关 键 词：脑膜脓毒金黄杆菌 感染 耐药性 

分 类 号：R378[医药卫生—病原生物学]