米索前列醇联合碧兰麻在人工流产中的应用  

Application of Misoprostol and Primacaine in Artificial Abortion

作　　者：李晖[1] 王俊丰[1] 

机构地区：[1]秦皇岛市第二医院,河北秦皇岛066600

出　　处：《中国现代应用药学》2012年第2期175-178,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的分析米索前列醇联合碧兰麻在人工流产中的疗效。方法随机抽取观察组和对照组各100例,观察组术前4 h口服米索前列醇600μg,术前2 min,于宫旁3点、9点处,注射碧兰麻1.7 mL后行负压吸引术;对照组术前4 h口服米索前列醇600μg,行负压吸引术。结果观察组100(100%)例患者均无疼痛;对照组中15(15%)例中度疼痛,73(73%)例轻度疼痛,12(12%)例无疼痛;观察组98(98%)例能直接插入7号宫颈扩张器,2(2%)例直接插入6号宫颈扩张器;对照组97(97%)例能直接插入7号宫颈扩张器,3(3%)例直接插入6号宫颈扩张器;观察组手术时间与对照组相比明显缩短,出血量与对照组相比明显减少(P<0.05);观察组无PASS的发生,对照组发生PASS 3例。结论米索前列醇联合碧兰麻能有效松弛宫颈,避免术中疼痛,预防人工流产综合征的发生,减少术中出血量,缩短手术时间,适宜基层医院推广和应用。OBJECTIVE To analyze the effect of misoprostol and primacaine in artificial abortions. METHODS Two hundred cases were randomized into observation group and control group, 100 cases in each group. In the observation group, 600 μg misoprostol was orally administered 4 hours before the surgery, and 1.7 mL primacaine was injected at point 3 and point 9 of the mystera 2 minutes before the vaccum aspiration surgery. In the control group, 600 μg misoprostol was orally administered 4 hours before the surgery, without application of the primacaine. RESULTS In the observation group, none of the 100 patients reported pain in the whole procedure of the surgery. In the control group, 15（15%） patients reported moderate pain; 73（73%） patients reported mild pain; and 12（12%） patients did not report experience of pain. In the observation group, No.7 cervical dilator could be directly inserted in 98（98%） patients and No.6 cervical dilator could be directly inserted in 2（2%） patients. In the control group, No.7 cervical dilator could be directly inserted in 97（97%） patients and No.6 cervical dilator could be directly inserted in 3（3%） patients. Compared with the control group, operation time was significantly shortened, and the amount of bleeding was significantly reduced（P〈0.05）. No PASS occurred in the observation group and 3 cases of PASS occurred in the control group. CONCLUSION Primacaine combined with misoprostol can effectively loosen the cervix, thus prevent the pain in the surgery and the occurrence of artificial abortion syndrome. It can reduce the amount of bleeding and shorten the operation time. Therefore it is appropriate to be promoted and applied in primary hospitals.

关 键 词：米索前列醇 碧兰麻 人工流产 

分 类 号：R969.4[医药卫生—药理学]