五味止痛片的处方优化研究  

Formula optimization of Wuwei Zhitong Tablets

作　　者：汪星[1,2] 廖茂梁[2] 孙卫[2] 胡乔[1,2] 张铁军[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院,天津300193

出　　处：《现代药物与临床》2012年第1期23-26,共4页Drugs & Clinic

基　　金：国家重大新药创制专项(2009ZX09103-443)

摘　　要：目的对五味止痛片的处方进行优化。方法以颗粒的休止角、吸湿率、片芯硬度为指标,采用单因素试验优选五味止痛片的最佳处方。结果优选出最佳处方:以乳糖为填充剂,崩解剂乳糖、磷酸氢钙、预胶化淀粉的比例为2:2:1.5,使用92%乙醇作为湿润剂,用量约为粉末的20%。结论制得的五味止痛片表面光洁度、硬度符合薄膜包衣片工艺要求,工艺简便可行,适宜工业化生产。Objective To optimize the formula ofWuwei Zhitong Tablets Methods The best formula was optimized by single-factor test with repose angle, moisture absorption rate of the granula, and the hardness of tablets as indexes. Results The optimal formula was filling agent by using lactose, and the ratio of lactose, CaHPO4 and amylum pregelatinisatum as disintegrant with 2 ： 2 ： 1.5, the wetting agent was 92% ethanol with the 20% of total powder. Conclusion The tablets are smooth and glossy, and have optimum hardness in accordance with the requirement. The process is simple and valuable for industrial production.

关 键 词：五味止痛片 处方优化 吸湿率 湿润剂 

分 类 号：R282.71[医药卫生—中药学]