老年高血压患者体位性血压改变及其对神经认知障碍的影响  

Postural change in blood pressure in old-aged hypertensive patients and effects on neurocognitive disorder

作　　者：王莉莉[1] 刘占东[2] 赵莹莹[1] 张健[2] 李继梅[1] 

机构地区：[1]首都医科大学附属北京友谊医院神经内科,北京100050 [2]首都医科大学附属北京友谊医院医保中心神经内科,北京100050

出　　处：《临床和实验医学杂志》2012年第4期241-242,246,共3页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金专项基金(编号:81041019);国家科技支撑项目(编号:2012BAK21B02)

摘　　要：目的探索高龄干部人群中高血压患者体位造成血压变化的特点以及体位性血压改变与明显的神经认知障碍的关系。方法对入选77例高血压患者进行卧立位血压测量,体位性低血压(OH)定义为直立位后收缩压下降≥2.6 kPa(20 mmHg)或舒张压下降≥1.3 kPa(10 mmHg),将直立位后收缩压升高≥2.6 kPa(20 mmHg)定义为体位性高血压(OHT),无上述两种异常者定义为体位性血压正常(ONT)。结果在住院高血压患者中,OH发生率18.2%,OHT发生率为9.0%,3组在年龄方面无统计学差异,OH组明显的神经认知障碍发生率显著高于ONT组。结论高龄高血压患者中,OH可能是加重神经认知障碍的重要因素之一。Objective To explore the characteristics of blood pressure change in posture among old-aged hypertensive patients and the association of orthostatic hypotension（OH） with major neurocognitive disorder.Methods Seventy seven hypertensive patients were included in this study and received orthostatic blood pressure measurement.OH was defined as a decrease of at least 20mmHg SBP or a decrease of DBP at least 10 mmHg while orthostatic hypertension（OHT） as an elevation of SBP by 20mmHg or more,others except these two conditions were classified into orthostatic normotension（ONT）.Results The prevalence rates of OH and OHT were 18.2% and 9.0% respectively in hypertensive patients.There is no significant difference in age among these three groups.The major neurocognitive disorder was more frequently seen in hypertensive patients with OH.Conclusion OH may be an important factor for aggravation of neurocognitive disorder.

关 键 词：老年人 体位性低血压 体位性高血压 神经认知障碍 

分 类 号：R544.1[医药卫生—心血管疾病]