简便的区域选择性合成3-O-乙基维生素C  

A Facile Regioselective Synthesis of 3-O-Ethy1-L-ascorbic Acid

作　　者：陈兵兵[1] 李淑娟[1] 谢一民[1] 马力[1] 刘利军[1] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《化学世界》2012年第1期48-51,共4页Chemical World

基　　金：宁夏科技攻关项目(10GG018);国家级创新实验项目(101074925)

摘　　要：采用微波辅助法在三乙胺的催化条件下,一步完成3-O-乙基维生素C的区域选择性烷基化反应,通过单因素和L9(34)正交试验确定了最佳反应条件为反应时间8 min,n(VC)∶n(三乙胺)∶n(硫酸二乙酯)=1.0∶1.15∶1.2,功率为200 W,反应总产率可达74.73%(HPLC),该反应条件温和,产率较高,产物选择性好,产物结构经IR和1H NMR得到了确证。3-O-Ethyl-L-ascorbic acid was regioselectively synthesized in the presence of triethylamine under microwave radiation.Through single-factor and orthogonal experiments,the optimal reaction conditions were： reaction time,8 min;mole ratio of L-ascorbic acid,triethylamine and diethyl sulfate,1.0∶1.15∶1.2;microwave power,200 W.The reaction was readily performed with good yield and good selectivity under mild conditions and convenient operations.The yield of 3-O-ethyl-L-ascorbicacid acid was up to 74.73%（HPLC）.The product was determined by IR and 1H NMR spectroscopy.

关 键 词：微波辅助法 合成 3-O-乙基维生素C 

分 类 号：O626[理学—有机化学]