原因不明习惯性流产患者自身抗体检测的临床意义  

The clinical significance of autoantibodies for unexplained habitual abortion patients

作　　者：王焕信 刘国宁 马金栋[2] 

机构地区：[1]山东省潍坊市坊子区人民医院,山东潍坊261200 [2]山东省潍坊市人民医院,山东潍坊261041

出　　处：《中国当代医药》2012年第1期12-13,19,共3页China Modern Medicine

摘　　要：目的:通过对原因不明习惯性流产(HA)患者自身抗体的检测,探讨其自身抗体与发病的关系。方法:对106例原因不明的HA患者采用ELISA法检测血清抗心磷脂抗体(ACA)、抗子宫内膜抗体(EMAb)、抗精子抗体(ASAb),间接免疫荧光法测定抗核抗体(ANA),免疫印迹法检测可抽提核抗原抗体(ENA)和抗双链DNA抗体(ds-DNA),斑点法检测抗平滑肌抗体(SMA)、抗线粒体抗体(AMA)。结果:原发性和继发性HA患者ACA、EMAb、AsA、ANA、SMA阳性率差异无统计学意义(P>0.05),但与对照组相比差异有统计学意义(P<0.01)。原发性和继发性习惯性流产患者的URNP、ds-DNA、SSA、Sm、SSB、Jo-1、Scl-70差异无统计学意义。结论:原因不明性习惯性流产患者体内存在自身抗体,主要有ACA、EMAb、SMA、ANA等,自身抗体的存在是造成原因不明性习惯性流产的原因。Objective： To explore the relationship between autoantibodies and disease by unexplained habitual abortion （HA） in patients with autoantibodies. Methods： One hundred and six cases of unexplained HA detected by ELISA in patients with serum anti-cardiolipin antibodies （ACA）, anti-endometrial antibodies （EMAb）, anti-sperm antibodies （ASAb）, Indirect immunofluorescence determination of anti-nuclear antibody （ANA）, Western blot extractable nuclear antigen antibodies （ENA） and anti-double-stranded DNA antibodies （ds-DNA）, anti-smooth muscle antibodies were detected spots （SMA）, anti-mitochondrial antibody （AMA）. Results： Positive rate of ACA, EMAb, ASAb, ANA, SMA between essental and secondary HA patients was no significant difference （P0.05）, but there were significantly positive rate with control group （P0.05）, positive rate with URNP, ds-DNA, SSA, Sm, SSB, Jo-1, Scl-70 were undifferentiated among groups. Conclusion： Most HA patients have autobodly mostly are ACA, EMAb, ANA, ASAb, SMA etc.. Caused by the presence of autoantibodies is unexplained habitual abortion causes.

关 键 词：流产 习惯性 自身抗体 自身免疫 

分 类 号：R714.21[医药卫生—妇产科学]