天钩降压胶囊中天麻苷、丹皮酚在大鼠离体小肠的吸收动力学  

Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats' Intestinal

作　　者：张微[1] 李凌军[1] 王瑛兰[1] 

机构地区：[1]山东中医药大学药学院,济南250355

出　　处：《中国实验方剂学杂志》2012年第4期150-153,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"十一五"重大新药创制项目(2009ZX09103-403)

摘　　要：目的:研究天钩降压胶囊中有效成分的大鼠离体小肠吸收动力学。方法:采用外翻肠囊法,用HPLC测定不同取样时间肠内液天麻苷、丹皮酚的含量,计算累计吸收量,以天麻苷、丹皮酚的累计吸收量对时间作线性回归分析,计算吸收动力学参数。结果:天麻苷回归方程为Y=0.000 6X-0.012 8(r=0.993 0),Ka=6.0×10-5μg.min-1.cm-2,t1/2=1.16×104h;丹皮酚回归方程为Y=0.000 68X+0.001 1(r=0.983 5),Ka=6.8×10-5μg.min-1.cm-2,t1/2=1.02×104 h。结论:天钩降压胶囊中天麻苷、丹皮酚在大鼠离体小肠的吸收为一级动力学过程。Objective：To study the absorption kinetics of the active components of Tiangou Jangya capsules in rats＇ intestinal.Method：Using an improved rat everted gut sac model,gastrodin concentration and paeonol concentration were determined by HPLC.The concentration of cumulative absorption was calculated.The linear regression equation was figured through the concentration of cumulative absorption and time.The parameters were calculated.Result：The regression equation of gastrodin was Y=0.000 6X-0.012 8（r=0.993 0）,Ka=6.0×10-5 μg·min-1·cm-2,t1/2=1.16×104 h;the regression equation of paeonol was Y=0.000 68X＋0.001 1（r=0.983 5）,Ka=6.8×10-5 μg·min-1·cm-2,t1/2=1.02×104 h.Conclusion：The absorption of gastrodin and paeonol conforms to the first-order kinetics in rats＇intestinal.

关 键 词：天钩降压胶囊 天麻苷 丹皮酚 吸收动力学 高效液相色谱法 

分 类 号：R285.5[医药卫生—中药学]