维药芳香新塔花水提物的抗炎镇痛作用及其急性毒性  

Anti-flammatory and Antalgic Effects of Ziziphora clinopodioides and its Acute Toxicity

作　　者：沙爱龙[1] 陈红玲[1,2] 孟庆艳[3] 

机构地区：[1]塔里木大学动物科学学院新疆生产建设兵团塔里木畜牧科技重点实验室,新疆阿拉尔843300 [2]新疆农业大学农学院,乌鲁木齐830052 [3]塔里木盆地生物资源保护利用兵团重点实验室,新疆阿拉尔843300

出　　处：《中国实验方剂学杂志》2012年第4期202-204,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：塔里木盆地生物资源保护利用国家重点实验室培育基地开放项目(BRYB1005)

摘　　要：目的:研究维药芳香新塔花水提物的抗炎、镇痛作用及其急性毒性。方法:小鼠分别ig给予低、中、高剂量(0.5,1,2 g.kg-1)的芳香新塔花水提物,连续7 d,1次/d。采用二甲苯致小鼠耳廓肿胀及甲醛致小鼠足跖肿胀的方法,观察其抗炎作用;以冰醋酸致小鼠扭体反应,观察其镇痛作用。3组小鼠分别ig给予7.5,15,30 g.kg-1的芳香新塔花水提物1次,进行急性毒性试验。结果:芳香新塔花水提物0.5,1,2 g.kg-1对二甲苯致小鼠耳廓肿胀、甲醛致小鼠足肿胀及醋酸致小鼠扭体均有显著抑制作用(P<0.05);30 g.kg-1及以下剂量单次ig给药后小鼠全部存活,观察期内未见明显毒性反应。结论:芳香新塔花具有明显的抗炎镇痛作用。Objective：To study the anti-inflammatory,antalgic effects and acute toxicity of Ziziphora clinopodioides Lam.Method：The inhibition of auricle edema induced by xylene and paw edema induced by formaldehyde were used to test the anti-inflammation,pain caused by acetic acid in mice was used to evaluate the antalgic effect.Oral administration was used for acute toxicity tests.Result：Z.clinopodioides of low,medium and high dose groups on xylene in rats induced by Auricular swelling,foot swelling in mice induced by formaldehyde and acetic acid twisting had a significant inhibition in mice induced（P0.05）.All mouse were survived,and no toxic reaction was found in the observed period.Conclusion：Z.clinopodioides has obvious anti-inflammatory and antalgic effects.The clinical dosage of the tablets is within the safty range.

关 键 词：芳香新塔花 抗炎 镇痛 急性毒性 

分 类 号：R285.5[医药卫生—中药学]