血清可溶性间皮素相关肽在卵巢良恶性肿瘤鉴别诊断中的应用  

Clinical application of serum mesothelin in differential diagnosis of ovarian benign and malignant tumors

作　　者：刘丽萍[1] 吴小华 梁红霞[2] 李冬秀[2] 

机构地区：[1]武警8640部队医院妇产科,河北定州073000 [2]中国人民解放军白求恩国际和平医院妇产科,河北石家庄050082

出　　处：《中国实用妇科与产科杂志》2012年第2期137-139,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然科学基金(编号30572093);河北省自然科学基金(编号C2005000804)

摘　　要：目的探讨血清可溶性间皮素相关肽(SMRP)在卵巢良恶性肿瘤鉴别诊断中的临床意义。方法血清标本取自2008年1月至2010年7月白求恩国际和平医院100例卵巢肿物患者及40例健康志愿者,ELISA试剂盒测定血清SMRP,化学发光法测定血清CA125,比较血清SMRP和CA125在卵巢良恶性肿瘤中的分布,绘制SMRP的ROC曲线,确定最佳截断值,评价诊断效能。结果卵巢癌组血清SMRP高于良性肿瘤组和健康对照组(P=0.000),良性肿瘤组与健康对照组相比差异无统计学意义(P=0.072)。SMRP的最佳截断值为1.103nmol/L,敏感度(77.27%)稍低,但特异度(97.92%)明显高于CA125。与临床诊断一致性方面,SMRP略优于CA125。结论血清SMRP可能是卵巢良恶性肿瘤鉴别诊断的良好指标。Objective To investigate the clinical significance of serum mesothelin in differential diagnosis of ovarian be- nign and malignant tumors. Methods The serum SMRP concentrations of 100 cases with ovarian tumors and 40 healthy volunteers were determined by ELISA kit. The serum CA125 concentrations was determined by chemiluminescence tech- nique. Statistical comparison of serum SMRP and CA125 in the patients with,benign and malignant ovarian tumors. ROC curve was constructed to determine the best cutoff value and evaluate the diagnostic performance of SMRP. Results Ser- um SMRP level in ovarian cancer group were higher than other groups significantly（ P = 0. 000）. There was no signifi- cance between benign tumor group and healthy volunteers（ P = 0. 072）. The best cut-off value was 1. 103 nmol/L. The sensitivity （77. 27% ） of serum SMRP was lower slightly, but the specificity （97. 92% ） was higher than that of CA125. At the aspect of consistency with clinical diagnosis, SMRP was superior to CA125 slightly. Conclusion Serum SMRP may be a good marker to diagnose ovarian benign and malignant tumors differentially.

关 键 词：卵巢肿瘤 诊断 鉴别 可溶性间皮素相关肽 

分 类 号：R711.7[医药卫生—妇产科学]