超声药物释放空化动力学行为研究  

Investigation of Microbubble Dynamics in Drug Release by Ultrasound Cavitation

作　　者：梁士利[1] 韩冬[1] 徐美玲[1] 崔霜[1] 张玲[2] 

机构地区：[1]东北师范大学物理学院,吉林长春130024 [2]长春理工大学理学院,吉林长春130022

出　　处：《发光学报》2012年第2期182-186,共5页Chinese Journal of Luminescence

基　　金：吉林省科技发展项目(201105003);长春光学精密机械与物理研究所应用光学国家重点实验室开放基金项目(BE042311)

摘　　要：以直径1μm的脂质体为空化研究对象,从修正的Rayleigh空化方程入手,研究机械系数(MI)对300 kHz和1 MHz超声作用时空化效应的影响。脂质体的药物释放以超声作用前后脂质体中钙黄绿素的荧光强度为量度。模拟结果表明:在微泡振荡过程中,由超声波驱动产生的负向最大泡壁运动速度促使微泡半径从最大快速减小接近于零,微泡积聚到最大能量。对于300 kHz和1 MHz的激励超声,存在一个拐点(MI)值,当MI小于接近0.4时,1 MHz微泡半径变化幅度强于300 kHz;当MI>0.4时,300 kHz微泡半径变化幅度强于1 MHz。这一结果预示在此范围内,300 kHz的药物释放效果好于1 MHz。本研究为超声空化效应研究及超声药物释放应用提供了理论依据。The cavitation of a liposome microbubble dynamics in drug release was studied.The main objective of this work was to investigate the role by the mechanical index（MI） in the 300 kHz and 1MHz ultrasound.Several simulations indicated that bubble radius changes quickly from maximal value to zero by the driving frequency.Drug release was more efficient at 300 kHz compared to 1 MHz when MI was greater than 0.4.When the MI was less than 0.4,drug release was more efficient at 1 MHz compared to 300 kHz.The results demonstrate that ultrasound has a potential in enhancing drug release from liposome.

关 键 词：超声空化效应 脂质体药物释放 动力学行为 

分 类 号：O433[机械工程—光学工程]