血清半胱氨酸蛋白酶抑制剂C、视黄醇结合蛋白联合检测在诊断早期肾损伤中的临床意义  

Analysis on early diagnosis of hypertensive and type 2 diabetes nephropathies with cystatin C and retinol binding protein

作　　者：邵耀明[1] 倪芳颖[1] 马坚[1] 王琼[1] 

机构地区：[1]南京医科大学附属无锡人民医院医学检验科,江苏无锡214023

出　　处：《中国医药导报》2012年第2期49-50,共2页China Medical Herald

摘　　要：目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C,Cys C)和视黄醇结合蛋白(retinol binding protein,RBP)联合检测对诊断原发性高血压、2型糖尿病患者早期肾损害的临床价值。方法采用Beckman-Coulter全自动生化仪分别检测185例原发性高血压患者、193例2型糖尿病患者及30例健康对照组血清半胱氨酸蛋白酶抑制剂C、视黄醇结合蛋白、尿素氮(BUN)、肌酐(SCr)的含量。结果高血压及2型糖尿病患者血清半胱氨酸蛋白酶抑制剂C、视黄醇结合蛋白水平均显著高于对照组(P<0.01),血清尿素氮(BUN)、肌酐(SCr)水平与对照组比较差异无统计学意义(P>0.05)。结论血清半胱氨酸蛋白酶抑制剂C、视黄醇结合蛋白可作为诊断患者早期肾损害的敏感指标。Objective To explore the clinical significance of determining cystatin C（Cys C） and retinol binding protein（RBP） in diagnosis of early renal damage in patients with hypertension and type 2 diabetes.Methods Cys C and RBP were detected in 185 hypertension patients and 193 type 2 diabetes patients and 30 controls with auto chemistry analyzer,BUN and SCr were detected at the same time.Results Cys C and RBP in patients with hypertension and type 2 diabetes group were increased significantly compared with those of the control group（P〈0.01）;but there was no significant of BUN and SCr among the three groups（P〈0.05）.Conclusion Cys C and RBP are good diagnostic markers of early renal damage in patients with hypertension and type 2 diabetes.The combined examination of Cys C and RBP can be more helpful for the diagnosis of early renal damage.

关 键 词：血清半胱氨酸蛋白酶抑制剂C 血清视黄醇结合蛋白 肾损害 

分 类 号：R544.14[医药卫生—心血管疾病] R587.2[医药卫生—内科学]