穿膜肽的研究现状及应用  

Recent Proceeding and Application of Cell-Penetrating Peptides

作　　者：陈翀[1] 季守平[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850

出　　处：《生物技术通讯》2012年第1期142-147,共6页Letters in Biotechnology

摘　　要：以细胞内物质为靶标的药物(大分子、蛋白质、多肽及核酸)只有穿透细胞膜才能进一步发挥其药效。细胞穿透多肽(穿膜肽)是由少于30个氨基酸残基组成的小肽,它们能够通过与细胞膜相互作用而穿透细胞膜这一天然屏障。穿膜肽大致分为宿主防御肽、基于信号序列的穿膜肽和富含精氨酸的穿膜肽;穿膜肽进入细胞的机制尚未完全阐明,存在倒置微团模型、地毯式模型及打孔模型等假说。穿膜肽能够携带各种物质进入细胞的特性受到人们的关注。我们就穿膜肽的种类、穿膜机制,及其在生物影像学和生物递送系统中的应用做一综述。Cell membranes are the major obstacles which limited the effect of the drugs that bind to intracellular targets.Cell-penetrating peptides（CPP） usually consist of less than 30 amino acid with a remarkable capacity for membrane translocation.CPP could be classified into three groups,host defensed peptides,signal-sequence-based peptides,and arginine-rich peptides.Although the integrity mechanism of CCP is currently unkown,three models,the carpet model,the pore formation model,and the inverted micelle-mediated model were proposed.Recent application of CPP for the development of new cellular imaging tools,biosensors,or biomolecular delivery systems have been highlighted in the review.

关 键 词：穿膜肽 穿膜机制 药物递送 

分 类 号：Q516[生物学—生物化学]