文拉法辛与帕罗西汀治疗抑郁症74例对症研究  

A controlled study in the treatment of depression with venlafaxine and paroxetine

作　　者：刘桂英[1] 于宏春[1] 张会堂[1] 

机构地区：[1]山西省同煤集团三医院,037017

出　　处：《内蒙古中医药》2012年第1期1-2,共2页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：目的:探讨文拉法辛对抑郁症的疗效与安全性。方法:74例抑郁发作患者,随机分为文拉法辛组与帕罗西汀组,每组37例,分别给予文拉法辛与帕罗西仃治疗,疗程6周,以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果:治疗1-2周,文拉法辛组HAMD,HAMA评分均较帕罗西汀组显著下降(P<0.05),治疗4-6周,两组相仿(P>0.05)。文拉法辛组有效率和治愈率分别为75.7%和54.19%,帕罗西汀组有效率和治愈率分别为80.6%和61.19%,两者差异无显著性(P>0.05)。文拉法辛组不良反应发生率21.6%,较帕罗西汀组44%显著为低(P<0.05)。结论:文拉法辛治疗抑郁症疗效与帕罗西汀相似,安全有效,不良反应轻。Objective： To study the efficacy and a safety of velafaxine in the treatment of major depression. Method ： This was a randomized 6 weeks study .74 outpatients and inpatients diagnosed as depression were randomly assigned into verdafaxine group with venlafaxine （n=37） and paroxetine groap with paroxetine （n=37）.cllnical efficacy was evaluated using Hamilton depression scale（HAMD）and Hamilton anxiety Scale （HMA）,and adverse reactions and safety were assessed with theatment emergent symptom scale（TESS）. Results ：The mean values of HAMD and HAMA total scores in the study group was signiticantly lower than that in the control group at the end of first two weeks （all P〈0.05） but there was no significant differences between the two groups at the end of week 4,6（P〉0.05）.The response rate and remission rate were 75.7% and 54.1% for venlafaxine group and were 80.6% and 61.1% for paroxetine group respectively. There was no significant difference between two groups（P〉0.05）. The total incidence rates of side effect in paroxetine group were higher than that in verdufaxine group（P〈 0.05）. Conclusion：Venlafaxine and paroxetine have similar effects on major depression. However,venlafaxine has less side effects.

关 键 词：抑郁症 文拉法辛 帕罗西汀 副反应量表 

分 类 号：R971.4[医药卫生—药品]