奥沙利铂神经毒性机制及防治研究进展  

Oxaliplatin induced neurotoxicity:mechanism and therapy

作　　者：陈小兵[1,2] 吕慧芳[1,2] 陈贝贝[1,2] 罗素霞[1,2] 

机构地区：[1]郑州大学附属肿瘤医院 [2]河南省肿瘤医院内科,河南郑州450008

出　　处：《中国医药科学》2012年第3期38-40,共3页China Medicine And Pharmacy

基　　金：河南省医药卫生重大攻关项目;卫生部科研基金资助项目(WKJ2011010012)

摘　　要：奥沙利铂是第3代铂类抗癌药物,抗癌谱广、毒副反应轻微是其主要特点。但该药的外周神经毒性发生率却高达90%,是其剂量限制性毒性。现对奥沙利铂(乐沙定)神经毒性表现、分级、发生机制及防治策略进行综述,以便为奥沙利铂疗程持续和达到更好疗效、更小毒性提供依据。Oxaliplatin is the third generation of the platinum,is effective in the treatment of multiple solid tumors and also quite safe.However,there is a high incidence of peripheral neurotoxiciy,which is dose-limiting.In this article,the clinical manifestations,mechanism of neurotoxicity and therapy are reviewed to provide evidence in the efficacy and the safety of oxaliplatin for the continuous treatment of this disease.

关 键 词：奥沙利铂 神经毒性 药物副作用 

分 类 号：R979.1[医药卫生—药品]