含α-氨基膦酸酯齐墩果酸衍生物的合成  

Synthesis of Oleanolic Acid Derivatives Containing α-a minophosphate Moiety

作　　者：张燕[1] 谷利军[1] 宿连征[1] 张智平[1] 王锐[1] 

机构地区：[1]云南民族大学民族药资源化学国家民委-教育部重点实验室,云南昆明650500

出　　处：《安徽农业科学》2012年第5期2737-2738,共2页Journal of Anhui Agricultural Sciences

基　　金：教育部科学技术研究重点项目(0702118);教育部留学回国人员科研启动基金项目;民族药资源化学重点实验室开放基金项目(MJY090103)

摘　　要：[目的]研究新型α-氨基膦酸酯齐墩果酸衍生物的合成方法。[方法]以DMF/DCM混合溶剂为反应介质,在DCC/HOBt作用下,经缩合反应将3-氧代修饰的齐墩果酸拼接上α-氨基膦酸芳香酯。[结果]合成了4个水溶性好、结构新颖的α-氨基膦酸酯齐墩果酸衍生物。[结论]HOBt与DCC协同缩合制备新型的α-氨基膦酸酯齐墩果酸衍生物是一种高效实用的方法。[Objective] The aim was to seek diverse lead compounds,the novel oleanolic acid derivatives containing α-a minophosphate moiety were designed and synthesized.[Methods] The group α-a mino acid aromatic esters and 3-oxo-oleanolic acid were spliced by the DCC/HOBt condensation reactions in DMF/DCM mixed medium.[Results] The four high water-soluble α-a minophosphonate oleanolic acid derivatives were synthesized with the protocol of mild reaction conditions,less by-products,raw materials readily available.[Conclusion] HOBt and DCC co-condensation was a highly efficient and practical approach for preparation of novel α-a minophosphonate oleanolic acid derivatives.

关 键 词：齐墩果酸 Α-氨基膦酸酯 合成 

分 类 号：Q946[生物学—植物学]