带器妊娠妇女血清、绒毛及蜕膜组织铜离子含量相关分析  

The related study of first pregnancy women with Cu-IUD on copper content of blood serum and decidua, chorion tissues

作　　者：顾向应[1] 王昕[1] 郭丽娜[1] 何双[1] 修瑞杰[1] 

机构地区：[1]天津医科大学总医院妇产科,300052

出　　处：《中华医学杂志》2012年第5期324-326,共3页National Medical Journal of China

摘　　要：目的 通过测定放置含铜宫内节育器（Cu-IUD）后妊娠的妇女子宫蜕膜、胚胎绒毛及血清中铜离子的含量,为带器妊娠妇女组织铜离子的含量对子代胚胎的安全性提供参考数值.方法 2010年3至12月,于天津医科大学总医院妇产科计划生育门诊选取25例带Cu-IUD妊娠者作为试验组,同时选取25例同孕周正常妊娠者作为对照组,分别测定试验组和对照组的子宫蜕膜、胚胎绒毛及血清铜离子的含量.结果 测定带Cu-IUD妊娠组妇女的血清铜离子均值为（0.79±0.15） mg/L,子宫蜕膜、胚胎绒毛中铜离子含量均值分别为（0.91 ±0.51） mg/kg,（0.72±0.50） mg/kg;正常妊娠组妇女的血清铜离子均值为（0.71 ±0.15） mg/L,子宫蜕膜、胚胎绒毛中铜离子含量均值分别为（0.57±0.21） mg/kg,（0.46 ±0.21） mg/kg.试验组和对照组妇女血清铜离子的含量差异无统计学意义（P＞0.05）,蜕膜、绒毛中铜离子含量比较差异有统计学意义（P＜0.05）即试验组蜕膜、绒毛中铜离子含量相对较高.结论 Cu-IUD中的铜离子只是在宫腔局部释放产生作用,对于全身铜代谢没有影响.而带器妊娠妇女绒毛中高浓度的铜离子是否影响子代安全有待进一步研究.Objective Through determine the copper content of decidua,chorion and blood serum of first pregnancy women with Cu-IUD,we offer date for security of offspring.Methods March 2010 to December 2010,in family planning clinics of the general hospital of Tianjin medical university,we selected twenty-five first pregnancy women with Cu-IUD who intended to terminate pregnancy to be experimental group and twenty-five normal first pregnancy women who intended to terminate pregnancy to be control group,and determined the copper content of decidua,chorion and blood serum in experimental group and control group.Results The copper content of decidua,chorion and blood serum in experimental group is （0.91 ±0.51 ）mg/kg,（0.72 ± 0.50） mg/kg,（0.79 ± 0.15 ） mg/L; the copper content of decidua,chorion and blood serum in control group is（0.57 ± 0.21 ） mg/kg,（0.46 ± 0.21 ） mg/kg,（0.71 ± 0.15 ）mg/L.The copper content of blood serum has no significant difference between experimental group and control group （P 〉0.05）.The copper content of decidua,chorion of experimental group is higher than control group （ P 〈0.05）.Conclusion Copper ion released from Cu-IUD only has an influence on the uterus tissues,but having no influence on the copper metabolism all over the body.The effects of high copper content of chorion in first pregnancy women with Cu-IUD on the offspring security will be researched further.

关 键 词：铜 离子 宫内避孕器 绒毛膜 蜕膜 

分 类 号：R169.1[医药卫生—公共卫生与预防医学]