硫化氢在重症急性胰腺炎患者血浆中的表达及意义  

Expression and Significance of Plasma Hydrogen Sulfide in Severe Acute Pancreatitis

作　　者：黄惊鸿[1] 卢根林[1] 斯伟宏[1] 邓勇[2] 

机构地区：[1]浙江省义乌市中心医院普通外一科,义乌322000 [2]青海大学附属医院肝胆胰外科,西宁810000

出　　处：《中国中西医结合外科杂志》2012年第1期25-27,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：义乌市科研计划项目(10-3-19)

摘　　要：目的:探讨硫化氢(H2S)在重症急性胰腺炎患者血浆中的表达及意义。方法:重症急性胰腺炎(A组)患者40例,同期健康体检者40例为正常对照组(B组)。敏感硫电极法测定血浆H2S浓度,化学法测定血浆NO含量,采用ELISA检测血浆中TNF-α、IL-6、高敏C反应蛋白(hsCRP)表达。结果:A组TNF-α、IL-6、hsCRP、NO及H2S均显著高于B组(P<0.01),H2S与TNF-α、IL-6、hsCRP、NO呈正相关(r=0.612、0.743、0.629、0.649,P<0.01)。结论:内源性H2S是一种炎症介质,在重症急性胰腺炎中起促进炎症反应效应。Objective To investigate the expression and significance of serum hydrogen sulfide in acute severe pancreatitis.Methods There were 40 cases of acute severe pancreatitis in group A and 40 healthy persons in group B as control.Sensitive sulfur-rheophore assay was uesd to assay plasma hydrogen sulfide.Serum NO was detected by chemical method.Enzyme-linked immunoadsorbent assay （ELISA） was used to determine the levels of IL-6,hsCRP and TNF-αin plasma.Results The results of serum TNF-α,IL-6,hsCRP,NO,and hydrogen sulfide in group A were significantly higher than that in group B（P 0.01）.There was a positive correlation between hydrogen sulfide and TNF-α,IL-6,hsCRP,NO（r= 0.612,0.743,0.629,0.649,P 0.01）.Conclusion Endogenous hydrogen sulfide acted as a mediator of inflammation in severe acute pancreatitis.

关 键 词：急性胰腺炎 硫化氢 血浆 

分 类 号：R657.51[医药卫生—外科学]