毛细支气管炎患儿鼻咽抽吸物分析对预测反复喘息的意义  

Predictive significance of the nasopharyngeal aspirate analysis of bronchiolitis on recurrent wheeze

作　　者：李睿[1] 王吉安[1] 刘金生[1] 张春娟[1] 任学斌[2] 

机构地区：[1]临沂市人民医院儿科,山东临沂276003 [2]临沂市人民医院检验科,山东临沂276003

出　　处：《临床儿科杂志》2012年第2期128-130,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨鼻咽抽吸物分析对毛细支气管炎患儿反复喘息的预测价值。方法采集81例毛细支气管炎患儿鼻咽抽吸物,直接免疫荧光法检测病毒抗原,ELISA法测半胱氨酰白三烯(LTD4),并进行白细胞分类计数。随访2年,根据喘息复发次数分为非反复喘息组和反复喘息组,比较两组患儿鼻咽抽吸物的差异。结果完成随访的75例患儿中,反复喘息者17例,占随访人数的22.67%。非反复喘息和反复喘息患儿的鼻咽抽吸物中,LTD4含量分别为(198.49±91.95)pg/ml和(263.16±113.73)pg/ml,差异有统计学意义(P<0.05);呼吸道合胞病毒检出率分别为62.07%和64.71%,差异无统计学意义(P>0.05);细胞分类都以中性粒细胞为主,两组比较差异无统计学意义(P>0.05)。结论毛细支气管炎患儿鼻咽抽吸物LTD4水平检测可能可以作为预示反复喘息发生的筛选指标之一。Objective To explore predictive value of the nasopharyngeal aspirate(NPA)analysis of bronchiolitis on later recurrent wheeze.Methods The NPA of 81 in-patient infants with bronchiolitis was collected at admission,the viral antigens were detected by direct immunofluorescent assay,the levels of cysteinyl-leukotriene LTD4 were measured by ELISA and the white cells were classified.These patients were divided into recurrent group and non-recurrent group according to frequency of wheezing during 2-year follow-up,and difference of the NPA between two groups was assessed.Results Seventeen of 75(22.67%)followed up children developed recurrent wheezing.LTD4 level was(198.49 ± 91.95)pg/ml and(263.16 ± 113.73)pg/ml in non-recurrent and recurrent group respectively(P < 0.05).Positive respiratory syncytial virus detection rate in non-recurrent group and recurrent group was 62.07% and 64.71% respectively(P > 0.05).Neutrophils was predominant cell type in the NPA,no significant difference between two groups was found(P > 0.05).Conclusions LTD4 level of the NPA from bronchiolitis may be one of the screening indices which predict recurrent wheeze development.

关 键 词：毛细支气管炎 鼻咽抽吸物 白三烯 喘息 儿童 

分 类 号：R725.6[医药卫生—儿科]