阿奇霉素在支原体感染后气道炎症中的抗炎作用  

Anti-infection of azithromycin in treatment of airway inflammation caused by mycoplasma

作　　者：于艳艳[1] 赵德育[2] 庄焕自[1] 吴培培[1] 王刚[1] 张荣[1] 

机构地区：[1]江苏省连云港市妇幼保健院 [2]南京医科大学附属儿童医院,江苏南京210008

出　　处：《临床儿科杂志》2012年第2期179-182,共4页Journal of Clinical Pediatrics

基　　金：江苏省连云港市卫生局科研基金项目(No.9069)

摘　　要：目的探讨阿奇霉素在支原体感染后产生的呼吸道炎症中的抗炎效应。方法选择支原体肺炎合并初次喘息发作的患儿76例,所有患儿应用常规治疗,喘息症状控制后随机分成3组:A组阿奇霉素口服,B组布地奈德雾化吸入,C组空白对照。3组均治疗3个月,分别在住院当日、干预前、干预后抽取静脉血,采用ELISA方法检测血清IL-8、IL-4、INF-γ的浓度,随访6个月。采用SPSS15.0软件包完成数据统计分析。结果经3个月干预后,3组患儿的IL-8、IL-4、IL-4/IFN-γ水平均有所下降,以A组下降最多,与C组比较差异有统计学意义。B组干预后IL-4、IL-4/IFN-γ下降水平较大,与A组比较差异有统计学意义,而A组IL-8的下降明显大于B组,差异有统计学意义。A组与B组6个月内喘息再次发作人数,均较C组少,但差异无统计学意义。结论阿奇霉素对支原体感染的炎性细胞因子IL-8、IL-4及IL-4/IFN-γ具有下调作用,对IL-8的下调作用尤为明显,对支原体感染后产生的气道炎症具有一定的作用。Objective To explore the anti-inflammatory effect of azithromycin in the treatment of airway infection caused by mycoplasma.Methods Seventy-six cases with mycoplasma pneumonia combined initial wheezing,after symptom improved by routine treatment,were divided into three groups.Group A was given azithromycin orally,group B was given aerosol inhaled budisonide and group C was as control.Venous blood was drawn on the first day of admission,before intervention and after intervention.The serum levels of IL-8,IL-4 and INF-γ were tested by ELISA.The follow up visit lasted for 6 months.The Data were analyzed using SPSS15.0 software.Results The serum levels of IL-8,IL-4 and IL-4/INF-γ were decreased in three groups after 3 months treatment,especially in group A decreased at most and was significantly different from group C.The serum levels of IL-4 and IL-4/INF-γ in group B decreased significantly from that in group A after treatment.The serum level of IL-8 in group A decreased significantly from that in group B.For the number of recurrence of wheezing within 6 months,group A and B was fewer than that in group C without significantly difference among the three groups.Conclusions Azithromycin can decrease the levels of inflammatory cytokines of IL-8,IL-4 and IL-4/IFN-γ,particularly for IL-8,has certain treatment effect on the airway inflammation infected by mycoplasma.

关 键 词：阿奇霉素 支原体感染 白细胞介素-8 白细胞介素-4 Γ干扰素 

分 类 号：R725.6[医药卫生—儿科]